Solid-Phase Microextraction: A Complementary In Vivo Sampling Method to Microdialysis

Two's compliment: Solid‐phase microextraction (SPME) was validated against microdialysis (MD) in simultaneous targeted analysis of selected neurotransmitters in brain tissue. Complementary data was obtained from global brain profiling with both methods. MD extracts primarily polar species, and...

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Veröffentlicht in:	Angewandte Chemie International Edition 2013-11, Vol.52 (46), p.12124-12126
Hauptverfasser:	Cudjoe, Erasmus, Bojko, Barbara, de Lannoy, Inés, Saldivia, Victor, Pawliszyn, Janusz
Format:	Artikel
Sprache:	eng
Schlagworte:	analytical methods Animals Brain - metabolism Chromatography, High Pressure Liquid Dopamine - chemistry Dopamine - metabolism Fluoxetine - chemistry Fluoxetine - metabolism in vivo sampling liquid chromatography Mass Spectrometry metabolomics Microdialysis Neurotransmitter Agents - analysis Neurotransmitter Agents - isolation & purification Rats Serotonin - chemistry Serotonin - metabolism Solid Phase Microextraction
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