Solid-Phase Microextraction: A Complementary In Vivo Sampling Method to Microdialysis

Solid-Phase Microextraction: A Complementary In Vivo Sampling Method to Microdialysis

Two's compliment: Solid‐phase microextraction (SPME) was validated against microdialysis (MD) in simultaneous targeted analysis of selected neurotransmitters in brain tissue. Complementary data was obtained from global brain profiling with both methods. MD extracts primarily polar species, and...

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Veröffentlicht in:Angewandte Chemie International Edition 2013-11, Vol.52 (46), p.12124-12126
Hauptverfasser: Cudjoe, Erasmus, Bojko, Barbara, de Lannoy, Inés, Saldivia, Victor, Pawliszyn, Janusz
Format: Artikel
Sprache:eng
Schlagworte:
analytical methods
Animals
Brain - metabolism
Chromatography, High Pressure Liquid
Dopamine - chemistry
Dopamine - metabolism
Fluoxetine - chemistry
Fluoxetine - metabolism
in vivo sampling
liquid chromatography
Mass Spectrometry
metabolomics
Microdialysis
Neurotransmitter Agents - analysis
Neurotransmitter Agents - isolation & purification
Rats
Serotonin - chemistry
Serotonin - metabolism
Solid Phase Microextraction
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Zusammenfassung:Two's compliment: Solid‐phase microextraction (SPME) was validated against microdialysis (MD) in simultaneous targeted analysis of selected neurotransmitters in brain tissue. Complementary data was obtained from global brain profiling with both methods. MD extracts primarily polar species, and SPME detects semi hydrophobic and hydrophobic compounds, including lipids related to neurodegenerative diseases. RT=retention time.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201304538