Rationale and design of the familial hypercholesterolemia foundation CAscade SCreening for Awareness and DEtection of Familial Hypercholesterolemia registry

Background Familial hypercholesterolemia (FH) is a hereditary condition caused by various genetic mutations that lead to significantly elevated low-density lipoprotein cholesterol levels and resulting in a 20-fold increased lifetime risk for premature cardiovascular disease. Although its prevalence...

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Veröffentlicht in:	The American heart journal 2014-03, Vol.167 (3), p.342-349.e17
Hauptverfasser:	O’Brien, Emily C., PhD, Roe, Matthew T., MD, MHS, Fraulo, Elizabeth S., BSN, Peterson, Eric D., MD, MPH, Ballantyne, Christie M., MD, Genest, Jacques, MD, Gidding, Samuel S., MD, Hammond, Emma, BSc, PhD, Hemphill, Linda C., MD, Hudgins, Lisa C., MD, Kindt, Iris, MD, MPH, Moriarty, Patrick M., MD, Ross, Joyce, MSN, CRNP, Underberg, James A., MD, Watson, Karol, MD, Pickhardt, Dave, MBA, Rader, Daniel J., MD, Wilemon, Katherine, BS, Knowles, Joshua W., MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Atherosclerosis Cardiovascular Cardiovascular disease Child development Cholesterol Electronic Health Records Family medical history Foundations Genes Health Records, Personal Heart attacks Humans Hyperlipoproteinemia Type II - diagnosis Hyperlipoproteinemia Type II - genetics Hyperlipoproteinemia Type II - therapy Internet Lipids Longitudinal Studies Mass Screening - methods Mutation Public health Quality of life Registries Studies United States
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Beschreibung
Zusammenfassung:	Background Familial hypercholesterolemia (FH) is a hereditary condition caused by various genetic mutations that lead to significantly elevated low-density lipoprotein cholesterol levels and resulting in a 20-fold increased lifetime risk for premature cardiovascular disease. Although its prevalence in the United States is 1 in 300 to 500 individuals,
ISSN:	0002-8703 1097-6744
DOI:	10.1016/j.ahj.2013.12.008