Regulation of the rabbit ileal brush-border Na super(+)/H super(+) exchanger by an ATP-requiring Ca super(++)/calmodulin-mediated process

Regulation of the rabbit ileal brush-border Na super(+)/H super(+) exchanger by an ATP-requiring Ca super(++)/calmodulin-mediated process

Brush-border vesicles purified from rabbit ileal villus cells were used to evaluate how Ca super(++)/calmodulin (CaM) regulates the neutral linked NaCl absorptive process, part of which is a Na super(+)/H super(+) exchanger. The data are consistent with Ca super(++)/CaM acting via phosphorylation to...

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Veröffentlicht in:The Journal of clinical investigation 1988-01, Vol.82 (3), p.1091-1097
Hauptverfasser: Rood, R P, Emmer, E, Wesolek, J, McCullen, J, Husain, Z, Cohen, ME, Braithwaite, R S, Murer, H, Sharp, GWG, Donowitz, M
Format: Artikel
Sprache:eng
Schlagworte:
antiport
calcium
calmodulin
kidney
protons
sodium
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Zusammenfassung:Brush-border vesicles purified from rabbit ileal villus cells were used to evaluate how Ca super(++)/calmodulin (CaM) regulates the neutral linked NaCl absorptive process, part of which is a Na super(+)/H super(+) exchanger. The data are consistent with Ca super(++)/CaM acting via phosphorylation to regulate the ileal brush-border Na super(+)/H super(+) exchanger.
ISSN:0021-9738