Mycobacterium szulgai Chronic Multifocal Osteomyelitis in an Adolescent With Inherited STAT1 Deficiency

We report a 17-year-old patient with inherited STAT1 deficiency, who was diagnosed with Mycobacterium szulgai chronic multifocal osteomyelitis and responded well to the therapy with ethambutol, rifampicin and azithromycin. Seven other reported cases of M. szulgai osteomyelitis are reviewed. This is...

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Veröffentlicht in:	The Pediatric infectious disease journal 2013-12, Vol.32 (12), p.1345-1347
Hauptverfasser:	SHAMRIZ, Oded, ENGELHARD, Dan, RAJS, Andrea Psorn, KAIDAR-SHWARTZ, Hasia, CASANOVA, Jean-Laurent, AVERBUCH, Diana
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antibiotics, Antitubercular - pharmacology Antibiotics, Antitubercular - therapeutic use Bacterial arthritis and osteitis Bacterial diseases Biological and medical sciences Human bacterial diseases Humans Infectious diseases Male Medical sciences Microbial Sensitivity Tests Mycobacterium Infections, Nontuberculous - genetics Mycobacterium Infections, Nontuberculous - metabolism Mycobacterium Infections, Nontuberculous - microbiology Nontuberculous Mycobacteria - drug effects Nontuberculous Mycobacteria - isolation & purification Osteomyelitis - genetics Osteomyelitis - metabolism Osteomyelitis - microbiology STAT1 Transcription Factor - deficiency STAT1 Transcription Factor - genetics
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Zusammenfassung:	We report a 17-year-old patient with inherited STAT1 deficiency, who was diagnosed with Mycobacterium szulgai chronic multifocal osteomyelitis and responded well to the therapy with ethambutol, rifampicin and azithromycin. Seven other reported cases of M. szulgai osteomyelitis are reviewed. This is the first description of M. szulgai osteomyelitis in an adolescent with a primary immunodeficiency.
ISSN:	0891-3668 1532-0987
DOI:	10.1097/01.inf.0000437067.43859.4c