NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder

Highlight • Activation of inflammasome in major depressive disorder provide new insights into the pathogenesis and may represent a new therapeutic option for the disease.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2014-02, Vol.36, p.111-117
Hauptverfasser:	Alcocer-Gómez, Elísabet, de Miguel, Manuel, Casas-Barquero, Nieves, Núñez-Vasco, Jéssica, Sánchez-Alcazar, José Antonio, Fernández-Rodríguez, Ana, Cordero, Mario D
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Amitriptyline Antidepressants Carrier Proteins - metabolism Caspase 1 - metabolism Depression Depressive Disorder, Major - blood Depressive Disorder, Major - metabolism Female Humans Inflammasome Inflammasomes - metabolism Inflammation Interleukin-18 - blood Interleukin-1beta - blood Leukocytes, Mononuclear - metabolism Male Middle Aged NLR Family, Pyrin Domain-Containing 3 Protein Oxidative Stress Psychiatry
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Beschreibung
Zusammenfassung:	Highlight • Activation of inflammasome in major depressive disorder provide new insights into the pathogenesis and may represent a new therapeutic option for the disease.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2013.10.017