A Stochastic Two-Stage Model for Cancer Risk Assessment. I. The Hazard Function and the Probability of Tumor

We present a mathematical treatment of a two‐mutation model for carcinogenesis with time‐dependent parameters. This model has previously been shown to be consistent with epidemiologic and experimental data. An approximate hazard function used in previous papers is critically evaluated.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Risk Anal.; (United States) 1988-09, Vol.8 (3), p.383-392
Hauptverfasser:	Moolgavkar, Suresh H., Dewanji, Anup, Venzon, David J.
Format:	Artikel
Sprache:	eng
Schlagworte:	560300 - Chemicals Metabolism & Toxicology ANIMAL CELLS BIOLOGICAL EFFECTS BIOLOGY CARCINOGENESIS CARCINOGENS Cocarcinogenesis CYTOLOGY DIFFERENTIAL EQUATIONS DISEASES DOSE LIMITS DOSE-RESPONSE RELATIONSHIPS EQUATIONS GROWTH HAZARDS HEALTH HAZARDS HUMAN POPULATIONS Humans KOLMOGOROV EQUATION MATHEMATICAL MODELS Models, Statistical Multistage models NEOPLASMS Neoplasms - etiology PATHOGENESIS POPULATIONS PROBABILITY RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT Risk RISK ASSESSMENT SAFETY STANDARDS STATISTICAL MODELS STOCHASTIC PROCESSES TIME DEPENDENCE time-dependent dosing TUMOR CELLS
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We present a mathematical treatment of a two‐mutation model for carcinogenesis with time‐dependent parameters. This model has previously been shown to be consistent with epidemiologic and experimental data. An approximate hazard function used in previous papers is critically evaluated.
ISSN:	0272-4332 1539-6924
DOI:	10.1111/j.1539-6924.1988.tb00502.x