FeCl3 Catalyzed Regioselective C‑Alkylation of Indolylnitroalkenes with Amino Group Substituted Arenes

FeCl3 Catalyzed Regioselective C‑Alkylation of Indolylnitroalkenes with Amino Group Substituted Arenes

An efficient FeCl3 catalyzed protocol for the synthesis of amino functionalized indolyl­nitro­alkanes from easily available precursor indolyl­nitroalkenes and substituted amines has been developed. Regioselective C-alkylation in the presence of free amino substituted arenes occurred. The scope of th...

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Veröffentlicht in:Journal of organic chemistry 2014-02, Vol.79 (4), p.1842-1849
Hauptverfasser: Zanwar, Manoj R, Kavala, Veerababurao, Gawande, Sachin D, Kuo, Chun-Wei, Huang, Wen-Chang, Kuo, Ting-Shen, Huang, Hsiu-Ni, He, Chiu-Hui, Yao, Ching-Fa
Format: Artikel
Sprache:eng
Schlagworte:
Alkylation
Amines - chemistry
Catalysis
Chlorides - chemistry
Ferric Compounds - chemistry
Indoles - chemistry
Nitro Compounds - chemistry
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Beschreibung
Zusammenfassung:An efficient FeCl3 catalyzed protocol for the synthesis of amino functionalized indolyl­nitro­alkanes from easily available precursor indolyl­nitroalkenes and substituted amines has been developed. Regioselective C-alkylation in the presence of free amino substituted arenes occurred. The scope of this methodology shows good functional group tolerance, and further, this protocol was used to prepare indolyl­quinoline derivatives.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo4025368