Synthesis of Proline-Based N‑Heterocyclic Carbene Ligands

Synthesis of Proline-Based N‑Heterocyclic Carbene Ligands

The synthesis of proline-based N-heterocyclic carbene ligands is reported. An approach to a variety of proline-containing imidazolium NHC precursors is presented. The proline amino acids are shown to be compatible with peptide synthetic methods by incorporation into tripeptides. Following peptide sy...

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Veröffentlicht in:Organic letters 2014-02, Vol.16 (4), p.1033-1035
Hauptverfasser: Zhao, Yang, Gilbertson, Scott R
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Imidazoles - chemistry
Ligands
Methane - analogs & derivatives
Methane - chemical synthesis
Methane - chemistry
Molecular Structure
Proline - chemistry
Rhodium - chemistry
Stereoisomerism
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Zusammenfassung:The synthesis of proline-based N-heterocyclic carbene ligands is reported. An approach to a variety of proline-containing imidazolium NHC precursors is presented. The proline amino acids are shown to be compatible with peptide synthetic methods by incorporation into tripeptides. Following peptide synthesis, the carbene is generated and bound to rhodium.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol403465d