The synthesis of neurotensin antagonist SR 48692 for prostate cancer research
An improved synthesis of the molecule SR 48692 is presented and its use as a neurotensin antagonist biological probe for use in cancer research is described. The preparation includes an number of enhanced chemical conversions and strategies to overcome some of the limiting synthetic transformations...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry 2013-07, Vol.21 (14), p.4378-4387 |
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| container_end_page | 4387 |
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| container_issue | 14 |
| container_start_page | 4378 |
| container_title | Bioorganic & medicinal chemistry |
| container_volume | 21 |
| creator | Baxendale, I.R. Cheung, S. Kitching, M.O. Ley, S.V. Shearman, J.W. |
| description | An improved synthesis of the molecule SR 48692 is presented and its use as a neurotensin antagonist biological probe for use in cancer research is described. The preparation includes an number of enhanced chemical conversions and strategies to overcome some of the limiting synthetic transformations in the original chemical route.
An improved synthesis of the molecule SR 48692 is presented and its use as a neurotensin antagonist biological probe for use in cancer research is described. The preparation includes an number of enhanced chemical conversions and strategies to overcome some of the limiting synthetic transformations in the original chemical route. |
| doi_str_mv | 10.1016/j.bmc.2013.04.075 |
| format | Article |
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An improved synthesis of the molecule SR 48692 is presented and its use as a neurotensin antagonist biological probe for use in cancer research is described. The preparation includes an number of enhanced chemical conversions and strategies to overcome some of the limiting synthetic transformations in the original chemical route.</description><identifier>ISSN: 0968-0896</identifier><identifier>EISSN: 1464-3391</identifier><identifier>DOI: 10.1016/j.bmc.2013.04.075</identifier><identifier>PMID: 23721919</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>antagonists ; Cell Line, Tumor ; chemistry ; Dose-Response Relationship, Drug ; Humans ; Male ; Meclinertant ; Molecular Structure ; Neurotensin - antagonists & inhibitors ; Prostate cancer ; prostatic neoplasms ; Prostatic Neoplasms - drug therapy ; Pyrazoles - chemical synthesis ; Pyrazoles - chemistry ; Quinolines - chemical synthesis ; Quinolines - chemistry ; SR 48692</subject><ispartof>Bioorganic & medicinal chemistry, 2013-07, Vol.21 (14), p.4378-4387</ispartof><rights>2013 Elsevier Ltd</rights><rights>Copyright © 2013 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-73e90114b0d44ae88c58e9ff51508a3b2b7ff0f9e0e63944a1153b0f9178d3753</citedby><cites>FETCH-LOGICAL-c443t-73e90114b0d44ae88c58e9ff51508a3b2b7ff0f9e0e63944a1153b0f9178d3753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0968089613004148$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23721919$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baxendale, I.R.</creatorcontrib><creatorcontrib>Cheung, S.</creatorcontrib><creatorcontrib>Kitching, M.O.</creatorcontrib><creatorcontrib>Ley, S.V.</creatorcontrib><creatorcontrib>Shearman, J.W.</creatorcontrib><title>The synthesis of neurotensin antagonist SR 48692 for prostate cancer research</title><title>Bioorganic & medicinal chemistry</title><addtitle>Bioorg Med Chem</addtitle><description>An improved synthesis of the molecule SR 48692 is presented and its use as a neurotensin antagonist biological probe for use in cancer research is described. The preparation includes an number of enhanced chemical conversions and strategies to overcome some of the limiting synthetic transformations in the original chemical route.
An improved synthesis of the molecule SR 48692 is presented and its use as a neurotensin antagonist biological probe for use in cancer research is described. The preparation includes an number of enhanced chemical conversions and strategies to overcome some of the limiting synthetic transformations in the original chemical route.</description><subject>antagonists</subject><subject>Cell Line, Tumor</subject><subject>chemistry</subject><subject>Dose-Response Relationship, Drug</subject><subject>Humans</subject><subject>Male</subject><subject>Meclinertant</subject><subject>Molecular Structure</subject><subject>Neurotensin - antagonists & inhibitors</subject><subject>Prostate cancer</subject><subject>prostatic neoplasms</subject><subject>Prostatic Neoplasms - drug therapy</subject><subject>Pyrazoles - chemical synthesis</subject><subject>Pyrazoles - chemistry</subject><subject>Quinolines - chemical synthesis</subject><subject>Quinolines - chemistry</subject><subject>SR 48692</subject><issn>0968-0896</issn><issn>1464-3391</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EokvLD-ACPnJJOmM7cSxOqOJLaoXUj7PlOOOuV7tJsb1I_fd42cIR5mJp9PjVOw9jbxBaBOzPN-24860AlC2oFnT3jK1Q9aqR0uBztgLTDw0Mpj9hr3LeAIBQBl-yEyG1QINmxa5u18Tz41zWlGPmS-Az7dNSaM5x5m4u7n6ZYy785pqroTeChyXxh7Tk4gpx72ZPiSfK5JJfn7EXwW0zvX56T9nd50-3F1-by-9fvl18vGy8UrI0WpIBRDXCpJSjYfDdQCaEDjsYnBzFqEOAYAiol6YiiJ0c6wL1MEndyVP2_phbi_zYUy52F7On7dbNtOyzrTmgjTAa_48qoavAzhxQPKK-npcTBfuQ4s6lR4tgD8Ltxlbh9iDcgrLwu8nbp_j9uKPp748_hivw7ggEt1h3n2K2dzc1oTbEOkpU4sORoGrsZ6Rks49UvU4xkS92WuI_CvwCytGXsA</recordid><startdate>20130715</startdate><enddate>20130715</enddate><creator>Baxendale, I.R.</creator><creator>Cheung, S.</creator><creator>Kitching, M.O.</creator><creator>Ley, S.V.</creator><creator>Shearman, J.W.</creator><general>Elsevier Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20130715</creationdate><title>The synthesis of neurotensin antagonist SR 48692 for prostate cancer research</title><author>Baxendale, I.R. ; Cheung, S. ; Kitching, M.O. ; Ley, S.V. ; Shearman, J.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-73e90114b0d44ae88c58e9ff51508a3b2b7ff0f9e0e63944a1153b0f9178d3753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>antagonists</topic><topic>Cell Line, Tumor</topic><topic>chemistry</topic><topic>Dose-Response Relationship, Drug</topic><topic>Humans</topic><topic>Male</topic><topic>Meclinertant</topic><topic>Molecular Structure</topic><topic>Neurotensin - antagonists & inhibitors</topic><topic>Prostate cancer</topic><topic>prostatic neoplasms</topic><topic>Prostatic Neoplasms - drug therapy</topic><topic>Pyrazoles - chemical synthesis</topic><topic>Pyrazoles - chemistry</topic><topic>Quinolines - chemical synthesis</topic><topic>Quinolines - chemistry</topic><topic>SR 48692</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baxendale, I.R.</creatorcontrib><creatorcontrib>Cheung, S.</creatorcontrib><creatorcontrib>Kitching, M.O.</creatorcontrib><creatorcontrib>Ley, S.V.</creatorcontrib><creatorcontrib>Shearman, J.W.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Bioorganic & medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baxendale, I.R.</au><au>Cheung, S.</au><au>Kitching, M.O.</au><au>Ley, S.V.</au><au>Shearman, J.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The synthesis of neurotensin antagonist SR 48692 for prostate cancer research</atitle><jtitle>Bioorganic & medicinal chemistry</jtitle><addtitle>Bioorg Med Chem</addtitle><date>2013-07-15</date><risdate>2013</risdate><volume>21</volume><issue>14</issue><spage>4378</spage><epage>4387</epage><pages>4378-4387</pages><issn>0968-0896</issn><eissn>1464-3391</eissn><abstract>An improved synthesis of the molecule SR 48692 is presented and its use as a neurotensin antagonist biological probe for use in cancer research is described. The preparation includes an number of enhanced chemical conversions and strategies to overcome some of the limiting synthetic transformations in the original chemical route.
An improved synthesis of the molecule SR 48692 is presented and its use as a neurotensin antagonist biological probe for use in cancer research is described. The preparation includes an number of enhanced chemical conversions and strategies to overcome some of the limiting synthetic transformations in the original chemical route.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>23721919</pmid><doi>10.1016/j.bmc.2013.04.075</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0968-0896 |
| ispartof | Bioorganic & medicinal chemistry, 2013-07, Vol.21 (14), p.4378-4387 |
| issn | 0968-0896 1464-3391 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | antagonists Cell Line, Tumor chemistry Dose-Response Relationship, Drug Humans Male Meclinertant Molecular Structure Neurotensin - antagonists & inhibitors Prostate cancer prostatic neoplasms Prostatic Neoplasms - drug therapy Pyrazoles - chemical synthesis Pyrazoles - chemistry Quinolines - chemical synthesis Quinolines - chemistry SR 48692 |
| title | The synthesis of neurotensin antagonist SR 48692 for prostate cancer research |
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