The synthesis of neurotensin antagonist SR 48692 for prostate cancer research

An improved synthesis of the molecule SR 48692 is presented and its use as a neurotensin antagonist biological probe for use in cancer research is described. The preparation includes an number of enhanced chemical conversions and strategies to overcome some of the limiting synthetic transformations...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2013-07, Vol.21 (14), p.4378-4387
Hauptverfasser:	Baxendale, I.R., Cheung, S., Kitching, M.O., Ley, S.V., Shearman, J.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	antagonists Cell Line, Tumor chemistry Dose-Response Relationship, Drug Humans Male Meclinertant Molecular Structure Neurotensin - antagonists & inhibitors Prostate cancer prostatic neoplasms Prostatic Neoplasms - drug therapy Pyrazoles - chemical synthesis Pyrazoles - chemistry Quinolines - chemical synthesis Quinolines - chemistry SR 48692
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Beschreibung
Zusammenfassung:	An improved synthesis of the molecule SR 48692 is presented and its use as a neurotensin antagonist biological probe for use in cancer research is described. The preparation includes an number of enhanced chemical conversions and strategies to overcome some of the limiting synthetic transformations in the original chemical route. An improved synthesis of the molecule SR 48692 is presented and its use as a neurotensin antagonist biological probe for use in cancer research is described. The preparation includes an number of enhanced chemical conversions and strategies to overcome some of the limiting synthetic transformations in the original chemical route.
ISSN:	0968-0896 1464-3391
DOI:	10.1016/j.bmc.2013.04.075