Design of magnetic polyplexes taken up efficiently by dendritic cell for enhanced DNA vaccine delivery

Dendritic cells (DC) targeting vaccines require high efficiency for uptake, followed by DC activation and maturation. We used magnetic vectors comprising polyethylenimine (PEI)-coated superparamagnetic iron oxide nanoparticles, with hyaluronic acid (HA) of different molecular weights (

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Bibliographische Detailangaben
Veröffentlicht in:	Gene therapy 2014-02, Vol.21 (2), p.212-218
Hauptverfasser:	Nawwab AL-Deen, F M, Selomulya, C, Kong, Y Y, Xiang, S D, Ma, C, Coppel, R L, Plebanski, M
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/2504/133 631/61/2300/1851 631/61/24/590/1991 631/61/54/152 Animals Antigens, Protozoan - genetics Biomedical and Life Sciences Biomedicine Cell activation Cell Biology Cells Cytotoxicity Dendritic Cells Deoxyribonucleic acid DNA DNA vaccines Dosage and administration Drug delivery systems Drugs Endocytosis Ferric Compounds - chemistry Ferric Compounds - metabolism Gene Expression Gene Therapy Genetic Vectors Human Genetics Hyaluronic acid Hyaluronic Acid - pharmacology Iron oxides Magnetic fields Magnetic Phenomena Merozoite surface protein 1 Mice, Inbred C57BL Nanoparticles Nanoparticles - administration & dosage Nanoparticles - adverse effects Nanoparticles - chemistry Nanotechnology original-article Pharmaceutical research Plasmodium yoelii Plasmodium yoelii - genetics Polyethyleneimine - chemistry Polyethyleneimine - metabolism Properties Transfection Vaccines Vaccines, DNA - administration & dosage Vaccines, DNA - chemistry Vehicles
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