Design of magnetic polyplexes taken up efficiently by dendritic cell for enhanced DNA vaccine delivery

Design of magnetic polyplexes taken up efficiently by dendritic cell for enhanced DNA vaccine delivery

Dendritic cells (DC) targeting vaccines require high efficiency for uptake, followed by DC activation and maturation. We used magnetic vectors comprising polyethylenimine (PEI)-coated superparamagnetic iron oxide nanoparticles, with hyaluronic acid (HA) of different molecular weights (

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Bibliographische Detailangaben
Veröffentlicht in:Gene therapy 2014-02, Vol.21 (2), p.212-218
Hauptverfasser: Nawwab AL-Deen, F M, Selomulya, C, Kong, Y Y, Xiang, S D, Ma, C, Coppel, R L, Plebanski, M
Format: Artikel
Sprache:eng
Schlagworte:
631/250/2504/133
631/61/2300/1851
631/61/24/590/1991
631/61/54/152
Animals
Antigens, Protozoan - genetics
Biomedical and Life Sciences
Biomedicine
Cell activation
Cell Biology
Cells
Cytotoxicity
Dendritic Cells
Deoxyribonucleic acid
DNA
DNA vaccines
Dosage and administration
Drug delivery systems
Drugs
Endocytosis
Ferric Compounds - chemistry
Ferric Compounds - metabolism
Gene Expression
Gene Therapy
Genetic Vectors
Human Genetics
Hyaluronic acid
Hyaluronic Acid - pharmacology
Iron oxides
Magnetic fields
Magnetic Phenomena
Merozoite surface protein 1
Mice, Inbred C57BL
Nanoparticles
Nanoparticles - administration & dosage
Nanoparticles - adverse effects
Nanoparticles - chemistry
Nanotechnology
original-article
Pharmaceutical research
Plasmodium yoelii
Plasmodium yoelii - genetics
Polyethyleneimine - chemistry
Polyethyleneimine - metabolism
Properties
Transfection
Vaccines
Vaccines, DNA - administration & dosage
Vaccines, DNA - chemistry
Vehicles
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Beschreibung
Zusammenfassung:Dendritic cells (DC) targeting vaccines require high efficiency for uptake, followed by DC activation and maturation. We used magnetic vectors comprising polyethylenimine (PEI)-coated superparamagnetic iron oxide nanoparticles, with hyaluronic acid (HA) of different molecular weights (
ISSN:0969-7128
1476-5462
DOI:10.1038/gt.2013.77