Evaluation of protective effect of pVAX-TgMIC13 plasmid against acute and chronic Toxoplasma gondii infection in a murine model
Highlights • A DNA vaccine expressing T. gondii mic 13 was constructed and evaluated in Kunming mice. • pVAX-TgMIC13 induced significant lymphoproliferation, cytokine production and antibody responses. • Immunized mice showed increased survival time (21.3 days) and 57.14% reduction of brain cysts. •...
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| Veröffentlicht in: | Vaccine 2013-06, Vol.31 (31), p.3135-3139 |
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| container_issue | 31 |
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| container_title | Vaccine |
| container_volume | 31 |
| creator | Yuan, Zi-Guo Ren, Di Zhou, Dong-Hui Zhang, Xiu-Xiang Petersen, Eskild Li, Xiu-Zhen Zhou, Yang Yang, Gui-Lian Zhu, Xing-Quan |
| description | Highlights • A DNA vaccine expressing T. gondii mic 13 was constructed and evaluated in Kunming mice. • pVAX-TgMIC13 induced significant lymphoproliferation, cytokine production and antibody responses. • Immunized mice showed increased survival time (21.3 days) and 57.14% reduction of brain cysts. • T. gondii MIC13 is a potential candidate to be included in future vaccines against acute and chronic T. gondii infection. |
| doi_str_mv | 10.1016/j.vaccine.2013.05.040 |
| format | Article |
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Psychology ; Human protozoal diseases ; humans ; immunization ; Immunoglobulin G - blood ; Infectious diseases ; Lymphocyte Activation ; lymphocyte proliferation ; Medical sciences ; Mice ; Microbiology ; Micronemal protein 13 ; parasites ; Parasitic diseases ; Plasmids ; protective effect ; Protective immunity ; Protozoal diseases ; Protozoan Proteins - genetics ; Protozoan Proteins - immunology ; Protozoan Vaccines - genetics ; Protozoan Vaccines - immunology ; pVAX-TgMIC13 ; recombinant vaccines ; T-lymphocytes ; tachyzoites ; Toxoplasma ; Toxoplasma gondii ; Toxoplasmosis ; Toxoplasmosis - immunology ; Toxoplasmosis - prevention & control ; Vaccination ; Vaccine ; vaccine development ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Vaccines, DNA - genetics ; Vaccines, DNA - immunology ; virulence</subject><ispartof>Vaccine, 2013-06, Vol.31 (31), p.3135-3139</ispartof><rights>Elsevier Ltd</rights><rights>2013 Elsevier Ltd</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Ltd. 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Psychology</subject><subject>Human protozoal diseases</subject><subject>humans</subject><subject>immunization</subject><subject>Immunoglobulin G - blood</subject><subject>Infectious diseases</subject><subject>Lymphocyte Activation</subject><subject>lymphocyte proliferation</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Microbiology</subject><subject>Micronemal protein 13</subject><subject>parasites</subject><subject>Parasitic diseases</subject><subject>Plasmids</subject><subject>protective effect</subject><subject>Protective immunity</subject><subject>Protozoal diseases</subject><subject>Protozoan Proteins - genetics</subject><subject>Protozoan Proteins - immunology</subject><subject>Protozoan Vaccines - genetics</subject><subject>Protozoan Vaccines - immunology</subject><subject>pVAX-TgMIC13</subject><subject>recombinant vaccines</subject><subject>T-lymphocytes</subject><subject>tachyzoites</subject><subject>Toxoplasma</subject><subject>Toxoplasma gondii</subject><subject>Toxoplasmosis</subject><subject>Toxoplasmosis - immunology</subject><subject>Toxoplasmosis - prevention & control</subject><subject>Vaccination</subject><subject>Vaccine</subject><subject>vaccine development</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Vaccines, DNA - genetics</subject><subject>Vaccines, DNA - immunology</subject><subject>virulence</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkstu1DAUQCMEokPhEwBvkNhkuH4kdjagalSgUhGLTlF3luPYg4fELnYyoit-HaczgMRmWNmyzn34nlsUzzEsMeD6zXa5U1o7b5YEMF1CtQQGD4oFFpyWpMLiYbEAUrOSYbg5KZ6ktAWAiuLmcXFCKAfOmFgUP893qp_U6IJHwaLbGEajR7czyFibb_ePX85uyvXm08UKU3TbqzS4DqmNcj6NSOlpNEj5DumvMXin0Tr8CPeUQpvgO-eQ83OquYTzSKFhirlvNITO9E-LR1b1yTw7nKfF9fvz9epjefn5w8Xq7LLUFadjKSi2mtKKtw1wS6FrBWtbKmxnqWlbwpqaEksFbRtRc6AdCE4gn8I0GrOanhav93nzD79PJo1ycEmbvlfehClJXAHwBirCjqOMMiAVaZr_QAnPUydAjqO0bgits5-MVntUx5BSNFbeRjeoeCcxyFm-3MqDfDnLl1DJLD_HvTiUmNrBdH-iftvOwKsDoJJWvY3Ka5f-crzCpCY8cy_3nFVBqk3MzPVVrpRnhLkQdG7x3Z4w2dnOmSiTdsZr07mYVcsuuKPNvv0ng-5dXh_VfzN3Jm3DFH1eCIllIhLk1bzL8ypjClATQegvMHjrwQ</recordid><startdate>20130628</startdate><enddate>20130628</enddate><creator>Yuan, Zi-Guo</creator><creator>Ren, Di</creator><creator>Zhou, Dong-Hui</creator><creator>Zhang, Xiu-Xiang</creator><creator>Petersen, Eskild</creator><creator>Li, Xiu-Zhen</creator><creator>Zhou, Yang</creator><creator>Yang, Gui-Lian</creator><creator>Zhu, Xing-Quan</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>M7N</scope></search><sort><creationdate>20130628</creationdate><title>Evaluation of protective effect of pVAX-TgMIC13 plasmid against acute and chronic Toxoplasma gondii infection in a murine model</title><author>Yuan, Zi-Guo ; Ren, Di ; Zhou, Dong-Hui ; Zhang, Xiu-Xiang ; Petersen, Eskild ; Li, Xiu-Zhen ; Zhou, Yang ; Yang, Gui-Lian ; Zhu, Xing-Quan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c573t-831fc3357b907f30db84bb38fdf3ebb249632f383b986703d0872003d8e9c1463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Allergy and Immunology</topic><topic>animal models</topic><topic>Animals</topic><topic>Antibodies, Protozoan - blood</topic><topic>Antibody Formation</topic><topic>Applied microbiology</topic><topic>Biological and medical sciences</topic><topic>brain</topic><topic>Brain - parasitology</topic><topic>Cell Proliferation</topic><topic>cytokines</topic><topic>Cytokines - immunology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human protozoal diseases</topic><topic>humans</topic><topic>immunization</topic><topic>Immunoglobulin G - blood</topic><topic>Infectious diseases</topic><topic>Lymphocyte Activation</topic><topic>lymphocyte proliferation</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Microbiology</topic><topic>Micronemal protein 13</topic><topic>parasites</topic><topic>Parasitic diseases</topic><topic>Plasmids</topic><topic>protective effect</topic><topic>Protective immunity</topic><topic>Protozoal diseases</topic><topic>Protozoan Proteins - genetics</topic><topic>Protozoan Proteins - immunology</topic><topic>Protozoan Vaccines - genetics</topic><topic>Protozoan Vaccines - immunology</topic><topic>pVAX-TgMIC13</topic><topic>recombinant vaccines</topic><topic>T-lymphocytes</topic><topic>tachyzoites</topic><topic>Toxoplasma</topic><topic>Toxoplasma gondii</topic><topic>Toxoplasmosis</topic><topic>Toxoplasmosis - immunology</topic><topic>Toxoplasmosis - prevention & control</topic><topic>Vaccination</topic><topic>Vaccine</topic><topic>vaccine development</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><topic>Vaccines, DNA - genetics</topic><topic>Vaccines, DNA - immunology</topic><topic>virulence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yuan, Zi-Guo</creatorcontrib><creatorcontrib>Ren, Di</creatorcontrib><creatorcontrib>Zhou, Dong-Hui</creatorcontrib><creatorcontrib>Zhang, Xiu-Xiang</creatorcontrib><creatorcontrib>Petersen, Eskild</creatorcontrib><creatorcontrib>Li, Xiu-Zhen</creatorcontrib><creatorcontrib>Zhou, Yang</creatorcontrib><creatorcontrib>Yang, Gui-Lian</creatorcontrib><creatorcontrib>Zhu, Xing-Quan</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yuan, Zi-Guo</au><au>Ren, Di</au><au>Zhou, Dong-Hui</au><au>Zhang, Xiu-Xiang</au><au>Petersen, Eskild</au><au>Li, Xiu-Zhen</au><au>Zhou, Yang</au><au>Yang, Gui-Lian</au><au>Zhu, Xing-Quan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of protective effect of pVAX-TgMIC13 plasmid against acute and chronic Toxoplasma gondii infection in a murine model</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2013-06-28</date><risdate>2013</risdate><volume>31</volume><issue>31</issue><spage>3135</spage><epage>3139</epage><pages>3135-3139</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Highlights • A DNA vaccine expressing T. gondii mic 13 was constructed and evaluated in Kunming mice. • pVAX-TgMIC13 induced significant lymphoproliferation, cytokine production and antibody responses. • Immunized mice showed increased survival time (21.3 days) and 57.14% reduction of brain cysts. • T. gondii MIC13 is a potential candidate to be included in future vaccines against acute and chronic T. gondii infection.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>23707448</pmid><doi>10.1016/j.vaccine.2013.05.040</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Vaccine, 2013-06, Vol.31 (31), p.3135-3139 |
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| subjects | Allergy and Immunology animal models Animals Antibodies, Protozoan - blood Antibody Formation Applied microbiology Biological and medical sciences brain Brain - parasitology Cell Proliferation cytokines Cytokines - immunology Female Fundamental and applied biological sciences. Psychology Human protozoal diseases humans immunization Immunoglobulin G - blood Infectious diseases Lymphocyte Activation lymphocyte proliferation Medical sciences Mice Microbiology Micronemal protein 13 parasites Parasitic diseases Plasmids protective effect Protective immunity Protozoal diseases Protozoan Proteins - genetics Protozoan Proteins - immunology Protozoan Vaccines - genetics Protozoan Vaccines - immunology pVAX-TgMIC13 recombinant vaccines T-lymphocytes tachyzoites Toxoplasma Toxoplasma gondii Toxoplasmosis Toxoplasmosis - immunology Toxoplasmosis - prevention & control Vaccination Vaccine vaccine development Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, DNA - genetics Vaccines, DNA - immunology virulence |
| title | Evaluation of protective effect of pVAX-TgMIC13 plasmid against acute and chronic Toxoplasma gondii infection in a murine model |
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