Evaluation of protective effect of pVAX-TgMIC13 plasmid against acute and chronic Toxoplasma gondii infection in a murine model

Highlights • A DNA vaccine expressing T. gondii mic 13 was constructed and evaluated in Kunming mice. • pVAX-TgMIC13 induced significant lymphoproliferation, cytokine production and antibody responses. • Immunized mice showed increased survival time (21.3 days) and 57.14% reduction of brain cysts. •...

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Veröffentlicht in:	Vaccine 2013-06, Vol.31 (31), p.3135-3139
Hauptverfasser:	Yuan, Zi-Guo, Ren, Di, Zhou, Dong-Hui, Zhang, Xiu-Xiang, Petersen, Eskild, Li, Xiu-Zhen, Zhou, Yang, Yang, Gui-Lian, Zhu, Xing-Quan
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology animal models Animals Antibodies, Protozoan - blood Antibody Formation Applied microbiology Biological and medical sciences brain Brain - parasitology Cell Proliferation cytokines Cytokines - immunology Female Fundamental and applied biological sciences. Psychology Human protozoal diseases humans immunization Immunoglobulin G - blood Infectious diseases Lymphocyte Activation lymphocyte proliferation Medical sciences Mice Microbiology Micronemal protein 13 parasites Parasitic diseases Plasmids protective effect Protective immunity Protozoal diseases Protozoan Proteins - genetics Protozoan Proteins - immunology Protozoan Vaccines - genetics Protozoan Vaccines - immunology pVAX-TgMIC13 recombinant vaccines T-lymphocytes tachyzoites Toxoplasma Toxoplasma gondii Toxoplasmosis Toxoplasmosis - immunology Toxoplasmosis - prevention & control Vaccination Vaccine vaccine development Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, DNA - genetics Vaccines, DNA - immunology virulence
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Beschreibung
Zusammenfassung:	Highlights • A DNA vaccine expressing T. gondii mic 13 was constructed and evaluated in Kunming mice. • pVAX-TgMIC13 induced significant lymphoproliferation, cytokine production and antibody responses. • Immunized mice showed increased survival time (21.3 days) and 57.14% reduction of brain cysts. • T. gondii MIC13 is a potential candidate to be included in future vaccines against acute and chronic T. gondii infection.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.05.040