Epitope engineering and molecular metrics of immunogenicity: A computational approach to VLP-based vaccine design

Highlights • An in-silico/ in vitro workflow to discover novel vaccine constructs is presented. • Binding affinity between antibody and epitope is demonstrated as a molecular metric of immunogenicity. • Multiple molecular metrics can be used to assess potential immunogenicity of a candidate vaccine...

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Veröffentlicht in:	Vaccine 2013-10, Vol.31 (42), p.4841-4847
Hauptverfasser:	Joshi, Harshad, Lewis, Kristen, Singharoy, Abhishek, Ortoleva, Peter J
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology antibodies Antibodies, Viral - immunology Antibody-virus binding Applied microbiology binding capacity Biological and medical sciences Computational Biology - methods Computer-aided vaccine design Design Drug Discovery - methods drug resistance engineering epitopes Epitopes - genetics Epitopes - immunology Fundamental and applied biological sciences. Psychology Hepatitis Hepatitis B virus Hepatitis B virus - genetics Hepatitis B virus - immunology Human papillomavirus Humans immune response Immunogenicity Infectious diseases Laboratories Microbiology Molecular metric of immunogenicity Nanoparticles Pandemics Papillomaviridae - genetics Papillomaviridae - immunology production costs Proteins Studies thermal stability vaccine development Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Vaccines, Virus-Like Particle - genetics Vaccines, Virus-Like Particle - immunology Viral Vaccines - genetics Viral Vaccines - immunology virus-like particles viruses
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Beschreibung
Zusammenfassung:	Highlights • An in-silico/ in vitro workflow to discover novel vaccine constructs is presented. • Binding affinity between antibody and epitope is demonstrated as a molecular metric of immunogenicity. • Multiple molecular metrics can be used to assess potential immunogenicity of a candidate vaccine nanoparticle.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.07.075