Synthesis of a novel series of artemisinin dimers with potent anticancer activity involving Sonogashira cross-coupling reaction

A series of C-10 acetal artemisinin dimers were synthesized using Sonogashira cross-coupling reaction. All these novel semisynthetic artemisinin dimers exhibited excellent growth inhibitory activity against Lung A-549 human cancer cell line.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2014-01, Vol.24 (1), p.237-239
Hauptverfasser:	Buragohain, Pori, Saikia, Bishwajit, Surineni, Naresh, Barua, Nabin C, Saxena, Ajit K, Suri, Nitasha
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitumor activity Artemisinins - chemical synthesis Artemisinins - chemistry Artemisinins - pharmacology Cell Line, Tumor Cell Proliferation - drug effects Dimerization Dose-Response Relationship, Drug Drug Screening Assays, Antitumor HeLa Cells Humans MCF-7 Cells Molecular Structure Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A series of C-10 acetal artemisinin dimers were synthesized using Sonogashira cross-coupling reaction. All these novel semisynthetic artemisinin dimers exhibited excellent growth inhibitory activity against Lung A-549 human cancer cell line.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2013.11.032