Family of human Na super(+),K super(+)-ATPase genes. Structure of the gene for the catalytic subunit ( alpha III-form) and its relationship with structural features of the protein

Family of human Na super(+),K super(+)-ATPase genes. Structure of the gene for the catalytic subunit ( alpha III-form) and its relationship with structural features of the protein

The primary structure of a gene of the Na super(+),K super(+)-ATPase multigenic family in the human genome has been determined. The gene corresponds to a hypothetical alpha III-form of the enzyme catalytic subunit. The gene comprises over 25,000 bp, and its protein coding region includes 23 exons an...

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Veröffentlicht in:FEBS letters 1988-01, Vol.233 (1), p.87-94
Hauptverfasser: Ovchinnikov, YuA, Monastyrskaya, G S, Broude, N E, Ushkaryov, YuA, Melkov, A M, Smirnov, YuV, Malyshev, I V, Allikmets, R L, Sverdlov, ED
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Sprache:eng
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Zusammenfassung:The primary structure of a gene of the Na super(+),K super(+)-ATPase multigenic family in the human genome has been determined. The gene corresponds to a hypothetical alpha III-form of the enzyme catalytic subunit. The gene comprises over 25,000 bp, and its protein coding region includes 23 exons and 22 introns. Possible correlation between structural features of the protein and location of introns in the gene are discussed.
ISSN:0014-5793