Outer membrane protein A (OmpA) from Shigella flexneri 2a: A promising subunit vaccine candidate

Highlights • Shigella flexneri 2a OmpA is crossreactive, conserved and surface exposed. • It gives 100% protection in mice against challenged with virulent S. flexneri 2a. • Both humoral and cell-mediated immunity are involved in that protective response. • OmpA coordinates innate and typ1-1 adaptiv...

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Veröffentlicht in:	Vaccine 2013-08, Vol.31 (36), p.3644-3650
Hauptverfasser:	Pore, Debasis, Chakrabarti, Manoj K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Allergy and Immunology Animals Antigens, Bacterial - immunology Applied microbiology Bacterial Outer Membrane Proteins - immunology Bacterial Vaccines - immunology Bacteriology Biological and medical sciences CD4+ T cells CD4-positive T-lymphocytes cell-mediated immunity chemokines childhood Cross Protection Dysentery, Bacillary - prevention & control Fundamental and applied biological sciences. Psychology Gram-negative bacteria Immunity, Cellular Immunity, Humoral Immunity, Innate immunodominant epitopes immunoglobulin A immunoglobulin G Macrophages Mice Microbiology Miscellaneous morbidity mortality Outer membrane protein A outer membrane proteins Shigella flexneri Shigella flexneri - immunology Shigella flexneri 2a shigellosis Toll-like receptor 2 Toll-Like Receptor 2 - immunology Toll-like receptors Vaccine vaccine development vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Zusammenfassung:	Highlights • Shigella flexneri 2a OmpA is crossreactive, conserved and surface exposed. • It gives 100% protection in mice against challenged with virulent S. flexneri 2a. • Both humoral and cell-mediated immunity are involved in that protective response. • OmpA coordinates innate and typ1-1 adaptive immune responses. • TLR2 plays fundamental role in the convergence of innate and adaptive immunity.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.05.100