Novel triple reuptake inhibitors with low risk of CAD associated liabilities: Design, synthesis and biological activities of 4-[(1S)-1-(3,4-dichlorophenyl)-2-methoxyethyl]piperidine and related compounds

A novel triple reuptake inhibitor with low potential of liabilities associated with cationic amphiphilic drug (CAD) was identified following an analysis of existing drugs. Low molecular weight (MW

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2013-08, Vol.21 (15), p.4600-4613
Hauptverfasser:	Ishichi, Yuji, Kimura, Eiji, Honda, Eiji, Yoshikawa, Masato, Nakahata, Takashi, Terao, Yasuko, Suzuki, Atsuko, Kawai, Takayuki, Arakawa, Yuuichi, Ohta, Hiroyuki, Kanzaki, Naoyuki, Nakagawa, Hideyuki, Terauchi, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressant Antidepressants Cationic amphiphilic drug (CAD) cortex CYP2D6 drugs hERG hydrophobicity Male Mice Mice, Inbred ICR Models, Molecular molecular weight Monoamine reuptake inhibition Neurotransmitter Uptake Inhibitors - chemical synthesis Neurotransmitter Uptake Inhibitors - chemistry Neurotransmitter Uptake Inhibitors - pharmacology Piperidine compounds piperidines Piperidines - chemical synthesis Piperidines - chemistry Piperidines - pharmacology PLsis Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism risk Structure-Activity Relationship tail Tail suspension test
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Beschreibung
Zusammenfassung:	A novel triple reuptake inhibitor with low potential of liabilities associated with cationic amphiphilic drug (CAD) was identified following an analysis of existing drugs. Low molecular weight (MW
ISSN:	0968-0896 1464-3391
DOI:	10.1016/j.bmc.2013.05.025