A comprehensive neuropsychological mapping battery for functional magnetic resonance imaging

Existing batteries for FMRI do not precisely meet the criteria for comprehensive mapping of cognitive functions within minimum data acquisition times using standard scanners and head coils. The goal was to develop a battery of neuropsychological paradigms for FMRI that can also be used in other brain imaging techniques and behavioural research. Participants were 61 healthy, young adult volunteers (48 females and 13 males, mean age: 22.25±3.39years) from the university community. The battery included 8 paradigms for basic (visual, auditory, sensory-motor, emotional arousal) and complex (language, working memory, inhibition/interference control, learning) cognitive functions. Imaging was performed using standard functional imaging capabilities (1.5-T MR scanner, standard head coil). Structural and functional data series were analysed using Brain Voyager QX2.9 and Statistical Parametric Mapping-8. For basic processes, activation centres for individuals were within a distance of 3–11mm of the group centres of the target regions and for complex cognitive processes, between 7mm and 15mm. Based on fixed-effect and random-effects analyses, the distance between the activation centres was 0–4mm. There was spatial variability between individual cases; however, as shown by the distances between the centres found with fixed-effect and random-effects analyses, the coordinates for individual cases can be used to represent those of the group. The findings show that the neuropsychological brain mapping battery described here can be used in basic science studies that investigate the relationship of the brain to the mind and also as functional localiser in clinical studies for diagnosis, follow-up and pre-surgical mapping. •Paradigms activated the relevant target areas to a satisfactory degree.•The speed by which the battery is administered can save the costs on FMRI.•Paradigms can be used as benchmarks and support cross-laboratory comparisons.•The battery investigates the relationship between mental and brain processes.•It can be used for presurgical mapping and enhance clinical diagnosis.