Intradermal fractional booster dose of inactivated poliomyelitis vaccine with a jet injector in healthy adults

Intradermal fractional booster dose of inactivated poliomyelitis vaccine with a jet injector in healthy adults

Highlights • RCT: fractional dose (1/5th) IM and ID IPV booster vaccine with a jet injector. • Somewhat weaker antibody response with fractional dose ID than full dose IM IPV. • Significantly weaker response after fractional dose IM vaccination. • After 1 year no difference between fractional dose I...

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Veröffentlicht in:Vaccine 2013-08, Vol.31 (36), p.3688-3694
Hauptverfasser: Soonawala, Darius, Verdijk, Pauline, Wijmenga-Monsuur, Alienke J, Boog, Claire J, Koedam, Patrick, Visser, Leo G, Rots, Nynke Y
Format: Artikel
Sprache:eng
Schlagworte:
administered dose
Adult
adults
affordability
Allergy and Immunology
Antibodies
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
Antibody Formation
Antigens
Applied microbiology
Biological and medical sciences
blood serum
Confidence intervals
Developing countries
erythema
Female
Fundamental and applied biological sciences. Psychology
Human viral diseases
Humans
immune response
Immunization
Immunization, Secondary
Immunogenicity
Infectious diseases
Injections, Intradermal
Injections, Intramuscular
Injections, Jet
Intradermal
Jet injector
LDCs
Male
Medical sciences
Microbiology
Needle-free
Netherlands
neutralizing antibodies
Pain
Polio
Poliomyelitis
Poliomyelitis - prevention & control
Poliovirus
Poliovirus Vaccine, Inactivated - administration & dosage
Poliovirus Vaccine, Inactivated - adverse effects
Production capacity
randomized clinical trials
secondary immunization
Vaccination
Vaccination - instrumentation
Vaccination - methods
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Viral diseases
Viral diseases of the nervous system
volunteers
Young Adult
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Beschreibung
Zusammenfassung:Highlights • RCT: fractional dose (1/5th) IM and ID IPV booster vaccine with a jet injector. • Somewhat weaker antibody response with fractional dose ID than full dose IM IPV. • Significantly weaker response after fractional dose IM vaccination. • After 1 year no difference between fractional dose ID and full dose IM. • ID but not IM delivery of fractional dose IPV may suffice.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2013.05.104