Novel vaccine formulations against pertussis offer earlier onset of immunity and provide protection in the presence of maternal antibodies

Highlights • Novel vaccine formulation for pertussis. • Effective in the presence of maternal antibodies. • Highly effective in neonates. • Novel adjuvant platform. • Reduced number of immunizations, long lasting immunity, cost effective. • Mucosal immunization.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2013-06, Vol.31 (31), p.3148-3155
Hauptverfasser:	Polewicz, Monika, Gracia, Aleksandra, Garlapati, Srinivas, van Kessel, Jill, Strom, Stacy, Halperin, Scott A, Hancock, Robert E.W, Potter, Andrew A, Babiuk, Lorne A, Gerdts, Volker
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesins, Bacterial - immunology Adjuvants, Immunologic - administration & dosage Allergy and Immunology Animals Antibodies, Bacterial - blood Antibodies, Bacterial - immunology Applied microbiology Bacterial Load Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Hemagglutinins - immunology Immune system Immunity, Maternally-Acquired Immunization Immunoglobulin A - blood Immunoglobulin G - blood Infants Interference with maternal antibodies Maternal antibodies Medical research Mice Mice, Inbred BALB C Microbiology Neonatal vaccines Neonates Oligodeoxyribonucleotides Pertussis Pertussis Vaccine - immunology Pertussis Vaccine - therapeutic use Rodents Swine Th1-Th2 Balance Toxoids - immunology Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Virulence Factors, Bordetella - immunology Whooping cough Whooping Cough - immunology Whooping Cough - prevention & control
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Beschreibung
Zusammenfassung:	Highlights • Novel vaccine formulation for pertussis. • Effective in the presence of maternal antibodies. • Highly effective in neonates. • Novel adjuvant platform. • Reduced number of immunizations, long lasting immunity, cost effective. • Mucosal immunization.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.05.008