High prevalence of antibodies against canine adenovirus (CAV) type 2 in domestic dog populations in South Africa precludes the use of CAV-based recombinant rabies vaccines

Highlights • Investigated prevalence of antibodies against canine adenovirus (CAV) in South African dogs. • High level of antibodies against CAV present in dog populations (40–60%). • Evaluated recombinant CAV2 vaccine expressing rabies virus glycoprotein in presence of CAV antibodies. • Presence of...

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Veröffentlicht in:	Vaccine 2013-08, Vol.31 (38), p.4177-4182
Hauptverfasser:	Wright, N, Jackson, F.R, Niezgoda, M, Ellison, J.A, Rupprecht, C.E, Nel, L.H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenovirus Adenoviruses Adenoviruses, Canine - genetics Adenoviruses, Canine - immunology Administration, Oral Allergy and Immunology Animals Antibodies Antibodies, Neutralizing Antibodies, Viral - blood Antibodies, Viral - immunology Applied microbiology Baits Beagle Biological and medical sciences blood Canine adenovirus Canine distemper virus Canine parvovirus Carnivore protoparvovirus 1 Dog Diseases - immunology Dog Diseases - prevention & control Dogs Domestic animals Fundamental and applied biological sciences. Psychology glycoproteins host specificity Immunization Infections Microbiology Miscellaneous neutralizing antibodies oral administration oral vaccination Oral vaccines Rabies Rabies - immunology Rabies - prevention & control Rabies - veterinary Rabies Vaccines - administration & dosage Rabies Vaccines - genetics Rabies Vaccines - immunology Rabies virus recombinant vaccines Seroepidemiologic Studies seroprevalence South Africa Studies Treatment Outcome Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - immunology Veterinary medicine Virology
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Beschreibung
Zusammenfassung:	Highlights • Investigated prevalence of antibodies against canine adenovirus (CAV) in South African dogs. • High level of antibodies against CAV present in dog populations (40–60%). • Evaluated recombinant CAV2 vaccine expressing rabies virus glycoprotein in presence of CAV antibodies. • Presence of CAV antibodies hampers RABV-specific seroconversion in dogs.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.06.089