Post-acute serum eosinophil and neutrophil-associated cytokine/chemokine profile can distinguish between patients with neuromyelitis optica and multiple sclerosis; and identifies potential pathophysiological mechanisms – A pilot study

•29 Patients were studied: AQP4 Ab positive NMO (n=19) and MS (n=10).•Higher IL17a (p=0.0005), G-CSF (p=0.051) and CCL4 (p=0.086) in NMO.•IL17a (p=0.008), G-CSF (p

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2013-10, Vol.64 (1), p.90-96
Hauptverfasser:	Michael, B.D., Elsone, L., Griffiths, M.J., Faragher, B., Borrow, R., Solomon, T., Jacob, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over analytical methods antibodies Aquaporin 4 - immunology aquaporins Biomarkers - blood blood serum Cell Differentiation central nervous system cerebrospinal fluid Chemokine CCL11 - blood Chemokine CCL4 - blood chemokines Chemotaxis disease severity Eosinophil eosinophils Eosinophils - metabolism Female Granulocyte-Macrophage Colony-Stimulating Factor - blood Humans Male Middle Aged Multiple sclerosis Multiple Sclerosis - blood Multiple Sclerosis - metabolism myeloperoxidase Neuromyelitis optica Neuromyelitis Optica - blood Neuromyelitis Optica - metabolism neutrophils Neutrophils - metabolism parenchyma patients Peroxidase - blood Pilot Projects sclerosis Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	•29 Patients were studied: AQP4 Ab positive NMO (n=19) and MS (n=10).•Higher IL17a (p=0.0005), G-CSF (p=0.051) and CCL4 (p=0.086) in NMO.•IL17a (p=0.008), G-CSF (p
ISSN:	1043-4666 1096-0023
DOI:	10.1016/j.cyto.2013.07.019