Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus

This work describes the preparation of quinoline compounds as possible anti-bacterial agents. The synthesized quinoline derivatives show anti-bacterial activity towards Staphylococcus aureus. It is interesting to observe that the synthetic 5,7-dibromo-2-methylquinolin-8-ol (4) shows a similar minimu...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2014-01, Vol.24 (1), p.367-370
Hauptverfasser:	Lam, Kim-Hung, Gambari, Roberto, Lee, Kenneth Ka-Ho, Chen, Yi-Xin, Kok, Stanton Hon-Lung, Wong, Raymond Siu-Ming, Lau, Fung-Yi, Cheng, Chor-Hing, Wong, Wai-Yeung, Bian, Zhao-Xiang, Chan, Albert Sun-Chi, Tang, Johnny Cheuk-On, Chui, Chung-Hin
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Cell Death - drug effects Cell Line Dose-Response Relationship, Drug Humans Microbial Sensitivity Tests Molecular Structure Oxyquinoline - chemical synthesis Oxyquinoline - chemistry Oxyquinoline - pharmacology Staphylococcus aureus Staphylococcus aureus - drug effects Structure-Activity Relationship
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Zusammenfassung:	This work describes the preparation of quinoline compounds as possible anti-bacterial agents. The synthesized quinoline derivatives show anti-bacterial activity towards Staphylococcus aureus. It is interesting to observe that the synthetic 5,7-dibromo-2-methylquinolin-8-ol (4) shows a similar minimum inhibitory concentration of 6.25μg/mL as compared to that of methicillin (3.125μg/mL) against Staphylococcus aureus.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2013.10.072