Global real-time quantitative reverse transcription-polymerase chain reaction detecting proto-oncogenes associated with 14q32 chromosomal translocation as a valuable marker for predicting survival in multiple myeloma

Abstract CCND1 , FGFR3 and c-MAF mRNA expression of tumor samples from 123 multiple myeloma patients were analyzed by global RQ/RT-PCR. CCND1 , FGFR3 and c-MAF were positive in 44 (36%), 28 (23%) and 16 (13%) of patients, respectively. In 7 patients, both FGFR3 and c-MAF were positive. The expressio...

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Veröffentlicht in:	Leukemia research 2013-12, Vol.37 (12), p.1648-1655
Hauptverfasser:	Inagaki, Atsushi, Tajima, Emi, Uranishi, Miyuki, Totani, Haruhito, Asao, Yu, Ogura, Hiroka, Masaki, Ayako, Yoshida, Tatsuya, Mori, Fumiko, Ito, Asahi, Yano, Hiroki, Ri, Masaki, Kayukawa, Satoshi, Kataoka, Takae, Kusumoto, Shigeru, Ishida, Takashi, Hayami, Yoshihito, Hanamura, Ichiro, Komatsu, Hirokazu, Inagaki, Hiroshi, Matsuda, Yasufumi, Ueda, Ryuzo, Iida, Shinsuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers, Tumor - genetics C-MAF Case-Control Studies CCND1 Chromosomes, Human, Pair 14 - genetics Female FGFR3 FISH Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine Humans Male Middle Aged Multiple myeloma Multiple Myeloma - diagnosis Multiple Myeloma - genetics Multiple Myeloma - mortality PCR Prognosis Proto-Oncogenes - genetics Real-Time Polymerase Chain Reaction Survival Survival Analysis Translocation, Genetic - genetics
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Zusammenfassung:	Abstract CCND1 , FGFR3 and c-MAF mRNA expression of tumor samples from 123 multiple myeloma patients were analyzed by global RQ/RT-PCR. CCND1 , FGFR3 and c-MAF were positive in 44 (36%), 28 (23%) and 16 (13%) of patients, respectively. In 7 patients, both FGFR3 and c-MAF were positive. The expression of c-MAF was independent unfavorable prognostic factors for overall survival (OS). Autologous stem cell transplantation improved progression-free survival of CCND1 -positive patients. Bortezomib, thalidomide or lenalidomide extended OS of FGFR3 and/or c-MAF -positive patients. Thus, CCND1 , FGFR3 and c-MAF mRNA expression can predict survival and is useful for planning stratified treatment strategies for myeloma patients.
ISSN:	0145-2126 1873-5835
DOI:	10.1016/j.leukres.2013.09.026