Improved inhibitory activities against tumor-cell migration and invasion by 15-benzylidene substitution derivatives of andrographolide

Inhibition of tumor cell migration and invasion of andrographolide derivatives were reported and the structure–activity relationships were analyzed. [Display omitted] In the present study, andrographolide (Andro, 1) derivatives were screened to identify potent inhibitors against tumor-cell migration...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2013-12, Vol.23 (23), p.6421-6426
Hauptverfasser:	Wu, Zhen-Wei, Xu, Hai-Wei, Dai, Gui-Fu, Liu, Meng-Jiao, Zhu, Li-Ping, Wu, Jian, Wang, Ya-Nan, Wu, Feng-Juan, Zhao, Dan, Gao, Ming-Fu, Nie, Shan-Shan, Han, Wei, Song, Jing-Hui, Liu, Hong-Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Andrographolide anticarcinogenic activity cell invasion Cell migration cell movement Cell Movement - drug effects Cell Proliferation - drug effects Derivative Diterpenes - chemical synthesis Diterpenes - chemistry Diterpenes - pharmacology diterpenoids Drug Screening Assays, Antitumor HT29 Cells Humans Invasion Migration MMP-9 neoplasms Neoplasms - drug therapy Neoplasms - pathology Structure-Activity Relationship structure-activity relationships
Online-Zugang:	Volltext
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