Improved inhibitory activities against tumor-cell migration and invasion by 15-benzylidene substitution derivatives of andrographolide

Inhibition of tumor cell migration and invasion of andrographolide derivatives were reported and the structure–activity relationships were analyzed. [Display omitted] In the present study, andrographolide (Andro, 1) derivatives were screened to identify potent inhibitors against tumor-cell migration...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Bioorganic & medicinal chemistry letters 2013-12, Vol.23 (23), p.6421-6426
Hauptverfasser: Wu, Zhen-Wei, Xu, Hai-Wei, Dai, Gui-Fu, Liu, Meng-Jiao, Zhu, Li-Ping, Wu, Jian, Wang, Ya-Nan, Wu, Feng-Juan, Zhao, Dan, Gao, Ming-Fu, Nie, Shan-Shan, Han, Wei, Song, Jing-Hui, Liu, Hong-Min
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Inhibition of tumor cell migration and invasion of andrographolide derivatives were reported and the structure–activity relationships were analyzed. [Display omitted] In the present study, andrographolide (Andro, 1) derivatives were screened to identify potent inhibitors against tumor-cell migration and invasion, and associated structure–activity relationships were studied. Compared to 1, compounds 8a–8d exhibited more potent activities against migration in SGC-7901, PC-3, A549, HT-29 and Ec109 cell lines. Improved activities against tumor-cell migration and invasion were proved to be associated with the down-regulation of MMPs.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2013.09.049