Improved inhibitory activities against tumor-cell migration and invasion by 15-benzylidene substitution derivatives of andrographolide
Inhibition of tumor cell migration and invasion of andrographolide derivatives were reported and the structure–activity relationships were analyzed. [Display omitted] In the present study, andrographolide (Andro, 1) derivatives were screened to identify potent inhibitors against tumor-cell migration...
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Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2013-12, Vol.23 (23), p.6421-6426 |
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Hauptverfasser: | , , , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Inhibition of tumor cell migration and invasion of andrographolide derivatives were reported and the structure–activity relationships were analyzed. [Display omitted]
In the present study, andrographolide (Andro, 1) derivatives were screened to identify potent inhibitors against tumor-cell migration and invasion, and associated structure–activity relationships were studied. Compared to 1, compounds 8a–8d exhibited more potent activities against migration in SGC-7901, PC-3, A549, HT-29 and Ec109 cell lines. Improved activities against tumor-cell migration and invasion were proved to be associated with the down-regulation of MMPs. |
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ISSN: | 0960-894X 1464-3405 |
DOI: | 10.1016/j.bmcl.2013.09.049 |