A novel (99m)Tc labelling strategy for the development of silica based particles for medical applications

A novel (99m)Tc labelling strategy for the development of silica based particles for medical applications

The reaction of high-valent fac-{(99m)TcO3}(+) complexes with alkenes ((3 + 2)-cycloaddition) has been used to develop a novel labelling procedure for silica based particles. This strategy can help to gain more detailed in vivo data of mesoporous silica by non-invasive radioimaging in the future. By...

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Veröffentlicht in:Dalton transactions : an international journal of inorganic chemistry 2014-03, Vol.43 (11), p.4260-4263
Hauptverfasser: Wuillemin, Michel A, Stuber, Wanda T, Fox, Thomas, Reber, Michael J, Brühwiler, Dominik, Alberto, Roger, Braband, Henrik
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes - chemistry
Cycloaddition Reaction
Humans
Models, Molecular
Norbornanes - chemistry
Organotechnetium Compounds - chemistry
Radiopharmaceuticals - chemistry
Silicon Dioxide - chemistry
Stereoisomerism
Technetium - chemistry
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Zusammenfassung:The reaction of high-valent fac-{(99m)TcO3}(+) complexes with alkenes ((3 + 2)-cycloaddition) has been used to develop a novel labelling procedure for silica based particles. This strategy can help to gain more detailed in vivo data of mesoporous silica by non-invasive radioimaging in the future. By applying norbornene as a coupling unit the (3 + 2)-cycloaddition reaction proceeds stereoselectively and with high reaction rates.
ISSN:1477-9234
DOI:10.1039/c3dt53019a