Polyclonal chromosomal evolution in a benign mixed salivary gland tumor

Banding analyses of a human benign pleomorphic adenoma in the parotid gland revealed a polyclonal pattern where structural rearrangements predominated. These deviations were different from the anomalies previously observed in 100 mixed tumors. The reason found for the differences in all likelihood w...

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Veröffentlicht in:	Cancer Genet. Cytogenet.; (United States) 1987-10, Vol.28 (2), p.237-243
Hauptverfasser:	Mark, Joachim, Ekedahl, Claes
Format:	Artikel
Sprache:	eng
Schlagworte:	560151 - Radiation Effects on Animals- Man Adenoma, Pleomorphic - genetics ADENOMAS Aged Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS BODY BODY AREAS CHROMOSOMAL ABERRATIONS Chromosome Aberrations - radiation effects DELAYED RADIATION EFFECTS DISEASES ELECTROMAGNETIC RADIATION Female Genetic Markers GLANDS Humans IONIZING RADIATIONS Karyotyping Medical sciences MUTATIONS NECK NEOPLASMS Neoplasms, Radiation-Induced - genetics ORGANS Otorhinolaryngology. Stomatology Parotid Neoplasms - genetics RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS RADIOINDUCTION SALIVARY GLANDS Tuberculosis, Lymph Node - radiotherapy Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology X RADIATION
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Beschreibung
Zusammenfassung:	Banding analyses of a human benign pleomorphic adenoma in the parotid gland revealed a polyclonal pattern where structural rearrangements predominated. These deviations were different from the anomalies previously observed in 100 mixed tumors. The reason found for the differences in all likelihood was x-ray treatment of tuberculous lymphadenitis in the neck during childhood. Implications regarding origin and development of pleomorphic adenomas are discussed.
ISSN:	0165-4608 1873-4456
DOI:	10.1016/0165-4608(87)90209-3