Acute and long term metabolic and parathyroid effects of fluoride in osteoporosis

Acute and long term metabolic and parathyroid effects of fluoride in osteoporosis

45 osteoporotic patients previously receiving mineral supplements were studied during subsequent additional treatment with sodium fluoride 60 mg daily for up to 5 years. First effects of fluoride therapy were a significant decline in serum calcium and phosphorus and rise in biologically active parat...

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Veröffentlicht in:Bone (New York, N.Y.) N.Y.), 1988-01, Vol.9 (4), p.251-251
Hauptverfasser: Stamp, TCB, Jenkins, M V, Katakity, M, Stainthorpe, E, Loveridge, N, Saphier, P W
Format: Artikel
Sprache:eng
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Zusammenfassung:45 osteoporotic patients previously receiving mineral supplements were studied during subsequent additional treatment with sodium fluoride 60 mg daily for up to 5 years. First effects of fluoride therapy were a significant decline in serum calcium and phosphorus and rise in biologically active parathyroid hormone (bio-PTH). Calcium balance showed zero overall change but fell significantly in those who showed least serum changes, in whom both calcium and phosphorus absorption diminished. Urine phosphorus excretion, however, fell equally throughout.
ISSN:8756-3282