Cytogenetic effects of amitriptyline hydrochloride in somatic and germ cells of mice

Amitriptyline hydrochloride, an antidepressant drug, was tested in mice for mutagenic effects in the somatic cells by the micronucleus test and in the germ cells by the air drying technique of Evans et al. Mice were treated orally with the drug at a dose of 70, 140 and 210 mg/kg body weight. The results indicate that the drug is capable of inducing mutations both in the mitotic and meiotic cells of mice.