Effect of tempol on the passive avoidance and novel object recognition task in diabetic rats

Highlights • Long-term learning and memory impairment was induced by streptozotocin. • Tempol improved spatial memory impairment in the novel object recognition task. • Tempol improved associative memory acquisition impairment in passive avoidance task. • Tempol improved associative memory retrieval...

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Veröffentlicht in:	Brain research bulletin 2014-02, Vol.101, p.51-56
Hauptverfasser:	Jabbarpour, Zahra, Shahidi, Siamak, Saidijam, Massoud, Sarihi, Abdolrahman, Hassanzadeh, Taghi, Esmaeili, Rasoul
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antioxidants - administration & dosage Antioxidants - adverse effects Antioxidants - pharmacology Avoidance Learning - drug effects Blood Glucose - drug effects Cognition Disorders - chemically induced Cognition Disorders - drug therapy Cognition Disorders - etiology Cyclic N-Oxides - administration & dosage Cyclic N-Oxides - adverse effects Cyclic N-Oxides - pharmacology Diabetes Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - drug therapy Male Memory Memory - drug effects Memory Disorders - chemically induced Memory Disorders - drug therapy Memory Disorders - etiology Neurology Neuropsychological Tests Oxidative Stress - drug effects Random Allocation Rat Rats Rats, Wistar Recognition (Psychology) - drug effects Spin Labels Streptozocin Task Performance and Analysis Tempol Time Factors
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Zusammenfassung:	Highlights • Long-term learning and memory impairment was induced by streptozotocin. • Tempol improved spatial memory impairment in the novel object recognition task. • Tempol improved associative memory acquisition impairment in passive avoidance task. • Tempol improved associative memory retrieval impairment in passive avoidance task.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2013.12.013