Distinct effects of haloperidol in the mediation of conditioned fear in the mesolimbic system and processing of unconditioned aversive information in the inferior colliculus
Highlights • AEPs were recorded from the IC after dopaminergic agonist and antagonist administration. • Haloperidol may reduce or heighten aversion, depending on the experimental conditions. • Opposite activity of D2 -mediated mechanisms of fear/anxiety processes was found. • Dopamine regulates unco...
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| Veröffentlicht in: | Neuroscience 2014-03, Vol.261, p.195-206 |
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| creator | Muthuraju, S Nobre, M.J Saito, V.M.N Brandao, M.L |
| description | Highlights • AEPs were recorded from the IC after dopaminergic agonist and antagonist administration. • Haloperidol may reduce or heighten aversion, depending on the experimental conditions. • Opposite activity of D2 -mediated mechanisms of fear/anxiety processes was found. • Dopamine regulates unconditioned fear at the IC and conditioned fear at rostral structures. |
| doi_str_mv | 10.1016/j.neuroscience.2013.11.063 |
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Psychiatry ; Psychopharmacology ; Quinpirole - pharmacology ; Rats ; Rats, Wistar ; Receptors, Dopamine D2 - agonists ; Receptors, Dopamine D2 - metabolism ; Reflex, Startle - drug effects ; Reflex, Startle - physiology ; Stress, Physiological - drug effects ; Stress, Physiological - physiology ; unconditioned fear ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience, 2014-03, Vol.261, p.195-206</ispartof><rights>IBRO</rights><rights>2013 IBRO</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2013 IBRO. Published by Elsevier Ltd. 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Psychiatry</subject><subject>Psychopharmacology</subject><subject>Quinpirole - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Dopamine D2 - agonists</subject><subject>Receptors, Dopamine D2 - metabolism</subject><subject>Reflex, Startle - drug effects</subject><subject>Reflex, Startle - physiology</subject><subject>Stress, Physiological - drug effects</subject><subject>Stress, Physiological - physiology</subject><subject>unconditioned fear</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUk2LFDEQbURxZ1f_gjSC4KXbVL562oMgu64KCx5U8BYySbWbMZ2MSffA_Cj_o2lmdBdP5hJSefVe8V5V1XMgLRCQr7ZtwDnFbBwGgy0lwFqAlkj2oFrBumNNJzh_WK0II7LhgtKz6jznLSlHcPa4OqOcrTmlYlX9unJ5csFMNQ4DminXcahvtY87TM5GX7tQT7dYj2idnlwMy7-JwbrlgbYeUKc7UI7ejRtn6nzIE461DrbepWgwZxe-L71zuN-t95iy22NhGGIajwontlIqM8RU5Lx3ZvZzflI9GrTP-PR0X1Rfr999ufzQ3Hx6__Hy7U1juBRT01vJCNlYLo3oO4EcO5RoBsYZBQGUwprRfqkaDWLD-dBZ2QtbbJOdFIRdVC-PvGX2nzPmSY0uG_ReB4xzVsD7HgQFQgv09RFqSiI54aB2yY06HRQQtcSltup-XGqJSwGoEldpfnbSmTfF4b-tf_IpgBcngM5G-yHpYFy-w60pFwC84K6OOCyu7B0mdZKzLpVUlY3u_-Z58w-N8S64ovwDD5i3cU6h-K5AZaqI-rws2LJfwAgQKb-x32dm0xY</recordid><startdate>20140307</startdate><enddate>20140307</enddate><creator>Muthuraju, S</creator><creator>Nobre, M.J</creator><creator>Saito, V.M.N</creator><creator>Brandao, M.L</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140307</creationdate><title>Distinct effects of haloperidol in the mediation of conditioned fear in the mesolimbic system and processing of unconditioned aversive information in the inferior colliculus</title><author>Muthuraju, S ; Nobre, M.J ; Saito, V.M.N ; Brandao, M.L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-9d6300bd46c5975e4e7e6ecf343215122183294e7eca15b44f7d695d754676503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>auditory-evoked potentials</topic><topic>Biological and medical sciences</topic><topic>Catalepsy - chemically induced</topic><topic>conditioned aversion</topic><topic>Conditioning, Classical - drug effects</topic><topic>Conditioning, Classical - physiology</topic><topic>dopamine</topic><topic>Dopamine Agonists - pharmacology</topic><topic>Dopamine Antagonists - pharmacology</topic><topic>Dopamine D2 Receptor Antagonists</topic><topic>Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation</topic><topic>Evoked Potentials, Auditory - drug effects</topic><topic>Evoked Potentials, Auditory - physiology</topic><topic>Fear - drug effects</topic><topic>Fear - physiology</topic><topic>fear-potentiated startle</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Haloperidol - pharmacology</topic><topic>Inferior Colliculi - drug effects</topic><topic>Inferior Colliculi - physiology</topic><topic>inferior colliculus</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psycholeptics: tranquillizer, neuroleptic</topic><topic>Psychology. Psychoanalysis. 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| subjects | Animals auditory-evoked potentials Biological and medical sciences Catalepsy - chemically induced conditioned aversion Conditioning, Classical - drug effects Conditioning, Classical - physiology dopamine Dopamine Agonists - pharmacology Dopamine Antagonists - pharmacology Dopamine D2 Receptor Antagonists Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation Evoked Potentials, Auditory - drug effects Evoked Potentials, Auditory - physiology Fear - drug effects Fear - physiology fear-potentiated startle Fundamental and applied biological sciences. Psychology Haloperidol - pharmacology Inferior Colliculi - drug effects Inferior Colliculi - physiology inferior colliculus Male Medical sciences Neurology Neuropharmacology Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Quinpirole - pharmacology Rats Rats, Wistar Receptors, Dopamine D2 - agonists Receptors, Dopamine D2 - metabolism Reflex, Startle - drug effects Reflex, Startle - physiology Stress, Physiological - drug effects Stress, Physiological - physiology unconditioned fear Vertebrates: nervous system and sense organs |
| title | Distinct effects of haloperidol in the mediation of conditioned fear in the mesolimbic system and processing of unconditioned aversive information in the inferior colliculus |
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