Distinct effects of haloperidol in the mediation of conditioned fear in the mesolimbic system and processing of unconditioned aversive information in the inferior colliculus

Highlights • AEPs were recorded from the IC after dopaminergic agonist and antagonist administration. • Haloperidol may reduce or heighten aversion, depending on the experimental conditions. • Opposite activity of D2 -mediated mechanisms of fear/anxiety processes was found. • Dopamine regulates unco...

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Veröffentlicht in:	Neuroscience 2014-03, Vol.261, p.195-206
Hauptverfasser:	Muthuraju, S, Nobre, M.J, Saito, V.M.N, Brandao, M.L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals auditory-evoked potentials Biological and medical sciences Catalepsy - chemically induced conditioned aversion Conditioning, Classical - drug effects Conditioning, Classical - physiology dopamine Dopamine Agonists - pharmacology Dopamine Antagonists - pharmacology Dopamine D2 Receptor Antagonists Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation Evoked Potentials, Auditory - drug effects Evoked Potentials, Auditory - physiology Fear - drug effects Fear - physiology fear-potentiated startle Fundamental and applied biological sciences. Psychology Haloperidol - pharmacology Inferior Colliculi - drug effects Inferior Colliculi - physiology inferior colliculus Male Medical sciences Neurology Neuropharmacology Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Quinpirole - pharmacology Rats Rats, Wistar Receptors, Dopamine D2 - agonists Receptors, Dopamine D2 - metabolism Reflex, Startle - drug effects Reflex, Startle - physiology Stress, Physiological - drug effects Stress, Physiological - physiology unconditioned fear Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights • AEPs were recorded from the IC after dopaminergic agonist and antagonist administration. • Haloperidol may reduce or heighten aversion, depending on the experimental conditions. • Opposite activity of D2 -mediated mechanisms of fear/anxiety processes was found. • Dopamine regulates unconditioned fear at the IC and conditioned fear at rostral structures.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.11.063