Neuregulin 1/ErbB4 enhances synchronized oscillations of prefrontal cortex neurons via inhibitory synapses

Highlights • NRG1 enhances synchrony of pyramidal neurons in the prefrontal cortex. • NRG1 also enhances synchrony of interneurons in the prefrontal cortex. • NRG1 enhances synchrony via inhibitory synapses but not gap junctions. • ErbB4 receptors mediate the effect of NRG1 on synchrony. • NRG1/ErbB...

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Veröffentlicht in:	Neuroscience 2014-03, Vol.261, p.107-117
Hauptverfasser:	Hou, X.-J, Ni, K.-M, Yang, J.-M, Li, X.-M
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Animals Biological and medical sciences ErbB4 Excitatory Amino Acid Agonists - pharmacology Fundamental and applied biological sciences. Psychology GABA Antagonists - pharmacology gamma oscillations Gap Junctions - drug effects Gap Junctions - physiology In Vitro Techniques inhibitory synapses Interneurons - drug effects Interneurons - physiology Kainic Acid - pharmacology Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic neuregulin 1 Neuregulin-1 - metabolism Neurology Neurons - drug effects Neurons - physiology Picrotoxin - pharmacology prefrontal cortex Prefrontal Cortex - drug effects Prefrontal Cortex - physiology Pyramidal Cells - drug effects Pyramidal Cells - physiology Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism Receptor, ErbB-4 Synapses - drug effects Synapses - physiology synchrony Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights • NRG1 enhances synchrony of pyramidal neurons in the prefrontal cortex. • NRG1 also enhances synchrony of interneurons in the prefrontal cortex. • NRG1 enhances synchrony via inhibitory synapses but not gap junctions. • ErbB4 receptors mediate the effect of NRG1 on synchrony. • NRG1/ErbB4 signaling enhances gamma oscillations in vivo.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.12.040