Subendocardial ischemia in hypertrophic cardiomyopathy
Abstract Hypertrophic cardiomyopathy (HCM) patients often develop subendocardial ischemia in the left ventricle without atherosclerotic coronary stenosis. Myocardial ischemia plays an important role in the pathophysiology of HCM, but diagnostic techniques for the detection of subendocardial ischemia...
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| Veröffentlicht in: | Journal of cardiology 2014-02, Vol.63 (2), p.89-94 |
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| container_end_page | 94 |
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| container_issue | 2 |
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| container_title | Journal of cardiology |
| container_volume | 63 |
| creator | Kawasaki, Tatsuya, MD, PhD Sugihara, Hiroki, MD, PhD |
| description | Abstract Hypertrophic cardiomyopathy (HCM) patients often develop subendocardial ischemia in the left ventricle without atherosclerotic coronary stenosis. Myocardial ischemia plays an important role in the pathophysiology of HCM, but diagnostic techniques for the detection of subendocardial ischemia have not been widely available. We developed specific techniques to quantify subendocardial ischemia on stress scintigraphy, and have compared the results with various clinical features in patients with HCM. This article reviews our understanding of subendocardial ischemia in HCM based on more than 20 years of experience. |
| doi_str_mv | 10.1016/j.jjcc.2013.10.005 |
| format | Article |
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Myocardial ischemia plays an important role in the pathophysiology of HCM, but diagnostic techniques for the detection of subendocardial ischemia have not been widely available. We developed specific techniques to quantify subendocardial ischemia on stress scintigraphy, and have compared the results with various clinical features in patients with HCM. This article reviews our understanding of subendocardial ischemia in HCM based on more than 20 years of experience.</description><identifier>ISSN: 0914-5087</identifier><identifier>EISSN: 1876-4738</identifier><identifier>DOI: 10.1016/j.jjcc.2013.10.005</identifier><identifier>PMID: 24268421</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Bridged Bicyclo Compounds, Heterocyclic ; Cardiomyopathies ; Cardiomyopathy, Hypertrophic - complications ; Cardiomyopathy, Hypertrophic - drug therapy ; Cardiovascular ; Diagnostic Imaging ; Diltiazem - administration & dosage ; Echocardiography ; Follow-Up Studies ; Humans ; Hypertrophic ; Ischemia ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Myocardial Ischemia - diagnosis ; Myocardial Ischemia - drug therapy ; Myocardial Ischemia - etiology ; Positron-Emission Tomography ; Prognosis ; Prospective Studies ; Pyrimidinones ; Subendocardium ; Tomography, Emission-Computed, Single-Photon ; Verapamil - administration & dosage</subject><ispartof>Journal of cardiology, 2014-02, Vol.63 (2), p.89-94</ispartof><rights>Japanese College of Cardiology</rights><rights>2013 Japanese College of Cardiology</rights><rights>Copyright © 2013 Japanese College of Cardiology. 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Myocardial ischemia plays an important role in the pathophysiology of HCM, but diagnostic techniques for the detection of subendocardial ischemia have not been widely available. We developed specific techniques to quantify subendocardial ischemia on stress scintigraphy, and have compared the results with various clinical features in patients with HCM. This article reviews our understanding of subendocardial ischemia in HCM based on more than 20 years of experience.</description><subject>Bridged Bicyclo Compounds, Heterocyclic</subject><subject>Cardiomyopathies</subject><subject>Cardiomyopathy, Hypertrophic - complications</subject><subject>Cardiomyopathy, Hypertrophic - drug therapy</subject><subject>Cardiovascular</subject><subject>Diagnostic Imaging</subject><subject>Diltiazem - administration & dosage</subject><subject>Echocardiography</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hypertrophic</subject><subject>Ischemia</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Ischemia - diagnosis</subject><subject>Myocardial Ischemia - drug therapy</subject><subject>Myocardial Ischemia - etiology</subject><subject>Positron-Emission Tomography</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Pyrimidinones</subject><subject>Subendocardium</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><subject>Verapamil - administration & dosage</subject><issn>0914-5087</issn><issn>1876-4738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2L1TAUhoMoznX0D7iQu3TTa07SJimIIINfMOBidB3yccpNbZuatAP996be0YULV4HD877kPIeQl0BPQEG86U9979yJUeBlcKK0eUQOoKSoasnVY3KgLdRVQ5W8Is9y7ikVtFXiKbliNROqZnAg4m61OPnoTPLBDMeQ3RnHYI5hOp63GdOS4nwO7vgbiOMWZ7Oct-fkSWeGjC8e3mvy_eOHbzefq9uvn77cvL-tXC3bpeK1a1nHOrQerfUAqoFWQGuVt51sfYNSUWiYai0XrGGdNUqiA2Ol5FZYfk1eX3rnFH-umBc9lh_iMJgJ45o11G3ZUQHnBWUX1KWYc8JOzymMJm0aqN596V7vvvTua58VXyX06qF_tSP6v5E_ggrw9gJg2fI-YNLZBZwc-pDQLdrH8P_-d__E3RCm4MzwAzfMfVzTVPxp0Jlpqu_2i-0HA04ppzXnvwARDZDF</recordid><startdate>201402</startdate><enddate>201402</enddate><creator>Kawasaki, Tatsuya, MD, PhD</creator><creator>Sugihara, Hiroki, MD, PhD</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201402</creationdate><title>Subendocardial ischemia in hypertrophic cardiomyopathy</title><author>Kawasaki, Tatsuya, MD, PhD ; Sugihara, Hiroki, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-34c92f2febdebbd118519619b8dbf79d5e78015289b36252fba87ec1ab773b6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Bridged Bicyclo Compounds, Heterocyclic</topic><topic>Cardiomyopathies</topic><topic>Cardiomyopathy, Hypertrophic - complications</topic><topic>Cardiomyopathy, Hypertrophic - drug therapy</topic><topic>Cardiovascular</topic><topic>Diagnostic Imaging</topic><topic>Diltiazem - administration & dosage</topic><topic>Echocardiography</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Hypertrophic</topic><topic>Ischemia</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial Ischemia - diagnosis</topic><topic>Myocardial Ischemia - drug therapy</topic><topic>Myocardial Ischemia - etiology</topic><topic>Positron-Emission Tomography</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Pyrimidinones</topic><topic>Subendocardium</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><topic>Verapamil - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawasaki, Tatsuya, MD, PhD</creatorcontrib><creatorcontrib>Sugihara, Hiroki, MD, PhD</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawasaki, Tatsuya, MD, PhD</au><au>Sugihara, Hiroki, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Subendocardial ischemia in hypertrophic cardiomyopathy</atitle><jtitle>Journal of cardiology</jtitle><addtitle>J Cardiol</addtitle><date>2014-02</date><risdate>2014</risdate><volume>63</volume><issue>2</issue><spage>89</spage><epage>94</epage><pages>89-94</pages><issn>0914-5087</issn><eissn>1876-4738</eissn><abstract>Abstract Hypertrophic cardiomyopathy (HCM) patients often develop subendocardial ischemia in the left ventricle without atherosclerotic coronary stenosis. Myocardial ischemia plays an important role in the pathophysiology of HCM, but diagnostic techniques for the detection of subendocardial ischemia have not been widely available. We developed specific techniques to quantify subendocardial ischemia on stress scintigraphy, and have compared the results with various clinical features in patients with HCM. This article reviews our understanding of subendocardial ischemia in HCM based on more than 20 years of experience.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>24268421</pmid><doi>10.1016/j.jjcc.2013.10.005</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of cardiology, 2014-02, Vol.63 (2), p.89-94 |
| issn | 0914-5087 1876-4738 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Bridged Bicyclo Compounds, Heterocyclic Cardiomyopathies Cardiomyopathy, Hypertrophic - complications Cardiomyopathy, Hypertrophic - drug therapy Cardiovascular Diagnostic Imaging Diltiazem - administration & dosage Echocardiography Follow-Up Studies Humans Hypertrophic Ischemia Magnetic Resonance Imaging Male Middle Aged Myocardial Ischemia - diagnosis Myocardial Ischemia - drug therapy Myocardial Ischemia - etiology Positron-Emission Tomography Prognosis Prospective Studies Pyrimidinones Subendocardium Tomography, Emission-Computed, Single-Photon Verapamil - administration & dosage |
| title | Subendocardial ischemia in hypertrophic cardiomyopathy |
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