Subendocardial ischemia in hypertrophic cardiomyopathy

Abstract Hypertrophic cardiomyopathy (HCM) patients often develop subendocardial ischemia in the left ventricle without atherosclerotic coronary stenosis. Myocardial ischemia plays an important role in the pathophysiology of HCM, but diagnostic techniques for the detection of subendocardial ischemia...

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Veröffentlicht in:	Journal of cardiology 2014-02, Vol.63 (2), p.89-94
Hauptverfasser:	Kawasaki, Tatsuya, MD, PhD, Sugihara, Hiroki, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Bridged Bicyclo Compounds, Heterocyclic Cardiomyopathies Cardiomyopathy, Hypertrophic - complications Cardiomyopathy, Hypertrophic - drug therapy Cardiovascular Diagnostic Imaging Diltiazem - administration & dosage Echocardiography Follow-Up Studies Humans Hypertrophic Ischemia Magnetic Resonance Imaging Male Middle Aged Myocardial Ischemia - diagnosis Myocardial Ischemia - drug therapy Myocardial Ischemia - etiology Positron-Emission Tomography Prognosis Prospective Studies Pyrimidinones Subendocardium Tomography, Emission-Computed, Single-Photon Verapamil - administration & dosage
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Zusammenfassung:	Abstract Hypertrophic cardiomyopathy (HCM) patients often develop subendocardial ischemia in the left ventricle without atherosclerotic coronary stenosis. Myocardial ischemia plays an important role in the pathophysiology of HCM, but diagnostic techniques for the detection of subendocardial ischemia have not been widely available. We developed specific techniques to quantify subendocardial ischemia on stress scintigraphy, and have compared the results with various clinical features in patients with HCM. This article reviews our understanding of subendocardial ischemia in HCM based on more than 20 years of experience.
ISSN:	0914-5087 1876-4738
DOI:	10.1016/j.jjcc.2013.10.005