Cognitive Functioning in Obstructive Lung Disease: Results from the United Kingdom Biobank

Cognitive Functioning in Obstructive Lung Disease: Results from the United Kingdom Biobank

Abstract Objectives To compare domains of cognitive functioning between persons with and without obstructive lung disease (OLD) and to analyze the relationship between cognitive functioning and the degree of airflow limitation. Design An observational population-based study. Setting This research wa...

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Veröffentlicht in:Journal of the American Medical Directors Association 2014-03, Vol.15 (3), p.214-219
Hauptverfasser: Cleutjens, Fiona A.H.M., MSc, Spruit, Martijn A., PhD, Ponds, Rudolf W.H.M., PhD, Dijkstra, Jeanette B., PhD, Franssen, Frits M.E., MD, PhD, Wouters, Emiel F.M., MD, PhD, Janssen, Daisy J.A., MD, PhD
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Biological Specimen Banks
Case-Control Studies
Cognition
Cognition Disorders - etiology
COPD
Female
Humans
Internal Medicine
Lung Diseases, Obstructive - psychology
lung function
Male
Medical Education
Middle Aged
neuropsychological functioning
Neuropsychological Tests
Regression Analysis
Self Care
self-management
Spirometry
UK Biobank
United Kingdom
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Zusammenfassung:Abstract Objectives To compare domains of cognitive functioning between persons with and without obstructive lung disease (OLD) and to analyze the relationship between cognitive functioning and the degree of airflow limitation. Design An observational population-based study. Setting This research was conducted using the United Kingdom Biobank Resource. Participants The study population consisted of 43,039 persons with complete data on cognitive functioning and spirometry. Measurements Cognitive functioning was compared between persons with and without OLD using linear regression analysis. The relationship between impairment in lung function and cognitive impairment was assessed among persons with OLD. Results Persons with OLD had significantly worse scores than persons without OLD on prospective memory [β = –0.15 (–0.22 to –0.09)], visuospatial memory [β round 1 = 0.06 (0.03‒0.10)]; β round 2 = 0.09 (
ISSN:1525-8610
1538-9375
DOI:10.1016/j.jamda.2013.12.007