Ketones as electrophiles in two component Baylis-Hillman reaction: a facile one-pot synthesis of substituted indolizines
2-Alkanoyl(aroyl)-pyridines have been successfully used for coupling with alkyl vinyl ketones under the influence of TMSOTf providing a facile protocol for the synthesis of substituted indolizines, thus demonstrating the application of ketones as electrophiles in a two component Baylis-Hillman react...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2014-03, Vol.12 (10), p.1551-1555 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | 2-Alkanoyl(aroyl)-pyridines have been successfully used for coupling with alkyl vinyl ketones under the influence of TMSOTf providing a facile protocol for the synthesis of substituted indolizines, thus demonstrating the application of ketones as electrophiles in a two component Baylis-Hillman reaction. |
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| ISSN: | 1477-0520 1477-0539 |
| DOI: | 10.1039/c3ob42064g |