Copper-Catalyzed Intermolecular Dehydrogenative Amidation/Amination of Quinoline N‑Oxides with Lactams/Cyclamines

Copper-Catalyzed Intermolecular Dehydrogenative Amidation/Amination of Quinoline N‑Oxides with Lactams/Cyclamines

C–H, N–H dehydrogenative coupling of quinoline N-oxides with lactams/cyclamines has been achieved in the presence of the Cu(OAc)2 catalyst to give good to excellent yields. This study provides a new strategy for the construction of a 2-aminoquinoline skeleton via direct functionalization of aryl C–H...

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Veröffentlicht in:Organic letters 2013-10, Vol.15 (20), p.5198-5201
Hauptverfasser: Li, Gang, Jia, Chunqi, Sun, Kai
Format: Artikel
Sprache:eng
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Zusammenfassung:C–H, N–H dehydrogenative coupling of quinoline N-oxides with lactams/cyclamines has been achieved in the presence of the Cu(OAc)2 catalyst to give good to excellent yields. This study provides a new strategy for the construction of a 2-aminoquinoline skeleton via direct functionalization of aryl C–H bonds.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol402324v