Efficient Microwave-Assisted Pd-Catalyzed Hydroxylation of Aryl Chlorides in the Presence of Carbonate

Efficient Microwave-Assisted Pd-Catalyzed Hydroxylation of Aryl Chlorides in the Presence of Carbonate

An efficient microwave-assisted, palladium-catalyzed hydroxylation of aryl chlorides in the presence of a weak base carbonate was developed, which rapidly converts aryl and heteroaryl chlorides to phenols, and can be used when the aryl chloride is functionalized with a ketone, aldehyde, ester, nitri...

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Veröffentlicht in:Organic letters 2012-07, Vol.14 (14), p.3688-3691
Hauptverfasser: Yu, Chao-Wu, Chen, Grace S, Huang, Chen-Wei, Chern, Ji-Wang
Format: Artikel
Sprache:eng
Schlagworte:
Carbonates - chemistry
Catalysis
Esters
Hydrocarbons, Chlorinated - chemistry
Hydroxylation
Microwaves
Molecular Structure
Nitriles - chemistry
Palladium - chemistry
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Zusammenfassung:An efficient microwave-assisted, palladium-catalyzed hydroxylation of aryl chlorides in the presence of a weak base carbonate was developed, which rapidly converts aryl and heteroaryl chlorides to phenols, and can be used when the aryl chloride is functionalized with a ketone, aldehyde, ester, nitrile, or amide.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol301523q