Palladium-Catalyzed Medium-Ring Formation for Construction of the Core Structure of Laurencia Oxacycles: Synthetic Study of Laurendecumallene B
Palladium-catalyzed medium-ring formation from a cyclic propargyl carbonate via a ring-opening and -closing cascade proceeded at the central carbon atom of the propargyl unit to provide a tetrahydro-2H-oxocine derivative bearing the core structure of laurencia oxacycle. The synthetic application of...
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Veröffentlicht in: | Organic letters 2013-06, Vol.15 (12), p.3046-3049 |
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Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Palladium-catalyzed medium-ring formation from a cyclic propargyl carbonate via a ring-opening and -closing cascade proceeded at the central carbon atom of the propargyl unit to provide a tetrahydro-2H-oxocine derivative bearing the core structure of laurencia oxacycle. The synthetic application of this reaction to a possible laurendecumallene B precursor is also presented. |
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ISSN: | 1523-7060 1523-7052 |
DOI: | 10.1021/ol401231y |