I2/TBHP-Catalyzed Chemoselective Amination of Indoles

I2/TBHP-Catalyzed Chemoselective Amination of Indoles

A novel I2/TBHP-mediated direct oxidative diamination reaction of indoles with anilines was developed. The reaction proceeded smoothly under aqueous and open air reaction conditions. This protocol provides a practical synthetic method for the synthesis of Tryptanthrin and the construction of N–C3 li...

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Veröffentlicht in:Organic letters 2013-10, Vol.15 (20), p.5226-5229
Hauptverfasser: Cai, Zhong-Jian, Wang, Shun-Yi, Ji, Shun-Jun
Format: Artikel
Sprache:eng
Schlagworte:
Amination
Amines - chemical synthesis
Amines - chemistry
Catalysis
Crystallography, X-Ray
Indoles - chemistry
Iodine - chemistry
Models, Molecular
Molecular Structure
tert-Butylhydroperoxide - chemistry
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Zusammenfassung:A novel I2/TBHP-mediated direct oxidative diamination reaction of indoles with anilines was developed. The reaction proceeded smoothly under aqueous and open air reaction conditions. This protocol provides a practical synthetic method for the synthesis of Tryptanthrin and the construction of N–C3 linked pyrrolidinoindolines which is the core structure of Psychotrimine.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol4023936