Nonalcoholic fatty liver disease and bariatric surgery in adolescents

Abstract Obesity is a multi-organ system disease with underlying insulin resistance and systemic chronic inflammation. Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of the underlying metabolic dysfunction. This review provides a highlight of the current understanding of NAFLD p...

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Veröffentlicht in:	Seminars in pediatric surgery 2014-02, Vol.23 (1), p.49-57
Hauptverfasser:	Holterman, AiXuan, MD, Gurria, Juan, MD, Tanpure, Smita, MS, DiSomma, Nerina, BA
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adolescent morbid obesity Bariatric Surgery Combined Modality Therapy Fatty Liver - diagnosis Fatty Liver - etiology Fatty Liver - therapy Humans Metabolic dysfunction Non-alcoholic Fatty Liver Disease Nonalcoholic fatty liver disease Obesity, Morbid - complications Obesity, Morbid - surgery Pediatric Obesity - complications Pediatric Obesity - surgery Pediatrics Risk Factors Surgery Treatment Outcome
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Beschreibung
Zusammenfassung:	Abstract Obesity is a multi-organ system disease with underlying insulin resistance and systemic chronic inflammation. Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of the underlying metabolic dysfunction. This review provides a highlight of the current understanding of NAFLD pathogenesis and disease characteristics, with updates on the challenges of NAFLD management in obese and severely obese (SO) patients and recommendations for the pediatric surgeons' role in the care of SO adolescents.
ISSN:	1055-8586 1532-9453
DOI:	10.1053/j.sempedsurg.2013.10.016