High-Efficiency Solid Phase Peptide Synthesis (HE-SPPS)

High-Efficiency Solid Phase Peptide Synthesis (HE-SPPS)

A series of improvements to the standard solid phase peptide synthesis (SPPS) process allowing for significant gains in product purity along with only a 4 min standard cycle time and a 90% reduction in total waste produced is reported. For example, syntheses of the well-known 65–74acyl carrier prote...

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Veröffentlicht in:Organic letters 2014-02, Vol.16 (3), p.940-943
Hauptverfasser: Collins, Jonathan M, Porter, Keith A, Singh, Sandeep K, Vanier, Grace S
Format: Artikel
Sprache:eng
Schlagworte:
Acyl Carrier Protein - chemical synthesis
Acyl Carrier Protein - chemistry
Amyloid beta-Peptides - chemical synthesis
Amyloid beta-Peptides - chemistry
Molecular Structure
Oligopeptides - chemical synthesis
Oligopeptides - chemistry
Peptide Fragments - chemical synthesis
Peptide Fragments - chemistry
Solid-Phase Synthesis Techniques
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Beschreibung
Zusammenfassung:A series of improvements to the standard solid phase peptide synthesis (SPPS) process allowing for significant gains in product purity along with only a 4 min standard cycle time and a 90% reduction in total waste produced is reported. For example, syntheses of the well-known 65–74acyl carrier protein (ACP) and 1–42β-amyloid peptides were accomplished with 93 and 72% purity (UPLC–MS) in only 44 and 229 min, respectively.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol4036825