Morphology-Based Plasmonic Nanoparticle Sensors: Controlling Etching Kinetics with Target-Responsive Permeability Gate

We present a sensing platform based on the morphological changes of plasmonic nanoparticles. Detection is achieved by using a stimulus-responsive polyelectrolyte-aptamer thin film to control the rate of diffusion of etchants that alter the shape and size of the nanoparticles. We show that the extent of morphological change and the colorimetric response depends on the amount of analyte bound. Contrary to conventional plasmonic sensors, our detection scheme does not rely on any interparticle interaction and is completely label-free, both in terms of the analyte and the capture probe. It presents new opportunities for designing facile, low-cost, and portable chip-based sensors for biodiagnostic and field analysis.