Copper-Catalyzed Intermolecular Trifluoromethylazidation of Alkenes: Convenient Access to CF3-Containing Alkyl Azides

A novel copper‐catalyzed intermolecular trifluoromethylazidation of alkenes has been developed under mild reaction conditions. A variety of CF3‐containing organoazides were directly synthesized from a wide range of olefins, including activated and unactivated alkenes, and the resulting products can be easily transformed into the corresponding CF3‐containing amine derivatives. The title reaction proceeds with a CF3+ reagent under mild reaction conditions. This transformation presents a broad substrate scope and good functional‐group tolerance. A variety of CF3‐containing organoazides are directly synthesized from a wide range of olefins, including activated and unactivated alkenes. The resulting products are easily transformed into the corresponding amine derivatives.