Serum Cystatin-C as a Marker of Acute Kidney Injury in the Newborn After Perinatal Hypoxia/Asphyxia
We evaluated cystatin‐C (cysC) in the umbilical blood as a predictor of acute kidney injury (AKI) after perinatal hypoxia/asphyxia compared with creatinine (Cr). One hundred full‐term newborns were enrolled in the study (50 in a group affected by perinatal hypoxia/asphyxia [AS] and 50 controls). Cys...
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| Veröffentlicht in: | Therapeutic apheresis and dialysis 2014-02, Vol.18 (1), p.57-67 |
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| creator | Treiber, Milena Gorenjak, Maksimiljan Pecovnik Balon, Breda |
| description | We evaluated cystatin‐C (cysC) in the umbilical blood as a predictor of acute kidney injury (AKI) after perinatal hypoxia/asphyxia compared with creatinine (Cr). One hundred full‐term newborns were enrolled in the study (50 in a group affected by perinatal hypoxia/asphyxia [AS] and 50 controls). CysC and Cr were measured in blood samples from the umbilical cord at birth (cysC‐umb and Cr‐umb) and from a peripheral vein 3 days later (cysC‐3 and Cr‐3). At birth, the mean level of cysC in healthy term babies was found to be 1.39 ± 0.19 mg/L and 1.34 ± 0.21 mg/L after 3 days of life, not significantly decreased (P = 0.137). The mean of cysC in the AS group was 2.12 ± 0.53 mg/L in cord blood and 1.56 ± 0.32 g/L in day 3 blood samples, also decreased (P |
| doi_str_mv | 10.1111/1744-9987.12054 |
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One hundred full‐term newborns were enrolled in the study (50 in a group affected by perinatal hypoxia/asphyxia [AS] and 50 controls). CysC and Cr were measured in blood samples from the umbilical cord at birth (cysC‐umb and Cr‐umb) and from a peripheral vein 3 days later (cysC‐3 and Cr‐3). At birth, the mean level of cysC in healthy term babies was found to be 1.39 ± 0.19 mg/L and 1.34 ± 0.21 mg/L after 3 days of life, not significantly decreased (P = 0.137). The mean of cysC in the AS group was 2.12 ± 0.53 mg/L in cord blood and 1.56 ± 0.32 g/L in day 3 blood samples, also decreased (P < 0.001) and different from the control (P < 0.001). Cr levels, determined simultaneously at birth were different (P = 0.001) between the control (62.74 ± 12.84 μmol/L) and AS (72.60 ± 15.55 μmol/L) group, significantly decreased after 3 days in both groups (P < 0.001). The receiver‐operating characteristic curve analysis, comparing AS and the control group, showed area under the curve for cysC‐umb, cysC‐3, Cr‐umb and Cr‐3 (0.918; 0.698; 0.692; 0.660). The highest diagnostic accuracy was achieved with a chosen cut‐off for cysC‐umb of 1.67 mg/L (sensitivity of 84.0%, specificity of 90.0%) or 1.69 mg/L (sensitivity of 82.0%, specificity of 94.0%). Our results indicate serum CysC is a more sensitive marker of glomerular filtration rate than Cr in the newborns.</description><identifier>ISSN: 1744-9979</identifier><identifier>EISSN: 1744-9987</identifier><identifier>DOI: 10.1111/1744-9987.12054</identifier><identifier>PMID: 24499085</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Acute kidney injury ; Acute Kidney Injury - blood ; Acute Kidney Injury - etiology ; Asphyxia ; Asphyxia Neonatorum - complications ; Biomarkers - blood ; Case-Control Studies ; Creatinine ; Creatinine - blood ; Cystatin C ; Cystatin C - blood ; Female ; Fetal Blood - metabolism ; Glomerular Filtration Rate ; Humans ; Hypoxia ; Infant, Newborn ; Male ; Newborn ; ROC Curve ; Sensitivity and Specificity</subject><ispartof>Therapeutic apheresis and dialysis, 2014-02, Vol.18 (1), p.57-67</ispartof><rights>2013 The Authors. Therapeutic Apheresis and Dialysis © 2013 International Society for Apheresis</rights><rights>2013 The Authors. Therapeutic Apheresis and Dialysis © 2013 International Society for Apheresis.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4054-166b11ff5535e0383c240ec148cdc12a029503f4a414a7afbec0660c375037323</citedby><cites>FETCH-LOGICAL-c4054-166b11ff5535e0383c240ec148cdc12a029503f4a414a7afbec0660c375037323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1744-9987.12054$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1744-9987.12054$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24499085$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Treiber, Milena</creatorcontrib><creatorcontrib>Gorenjak, Maksimiljan</creatorcontrib><creatorcontrib>Pecovnik Balon, Breda</creatorcontrib><title>Serum Cystatin-C as a Marker of Acute Kidney Injury in the Newborn After Perinatal Hypoxia/Asphyxia</title><title>Therapeutic apheresis and dialysis</title><addtitle>Ther Apher Dial</addtitle><description>We evaluated cystatin‐C (cysC) in the umbilical blood as a predictor of acute kidney injury (AKI) after perinatal hypoxia/asphyxia compared with creatinine (Cr). One hundred full‐term newborns were enrolled in the study (50 in a group affected by perinatal hypoxia/asphyxia [AS] and 50 controls). CysC and Cr were measured in blood samples from the umbilical cord at birth (cysC‐umb and Cr‐umb) and from a peripheral vein 3 days later (cysC‐3 and Cr‐3). At birth, the mean level of cysC in healthy term babies was found to be 1.39 ± 0.19 mg/L and 1.34 ± 0.21 mg/L after 3 days of life, not significantly decreased (P = 0.137). The mean of cysC in the AS group was 2.12 ± 0.53 mg/L in cord blood and 1.56 ± 0.32 g/L in day 3 blood samples, also decreased (P < 0.001) and different from the control (P < 0.001). Cr levels, determined simultaneously at birth were different (P = 0.001) between the control (62.74 ± 12.84 μmol/L) and AS (72.60 ± 15.55 μmol/L) group, significantly decreased after 3 days in both groups (P < 0.001). The receiver‐operating characteristic curve analysis, comparing AS and the control group, showed area under the curve for cysC‐umb, cysC‐3, Cr‐umb and Cr‐3 (0.918; 0.698; 0.692; 0.660). The highest diagnostic accuracy was achieved with a chosen cut‐off for cysC‐umb of 1.67 mg/L (sensitivity of 84.0%, specificity of 90.0%) or 1.69 mg/L (sensitivity of 82.0%, specificity of 94.0%). Our results indicate serum CysC is a more sensitive marker of glomerular filtration rate than Cr in the newborns.</description><subject>Acute kidney injury</subject><subject>Acute Kidney Injury - blood</subject><subject>Acute Kidney Injury - etiology</subject><subject>Asphyxia</subject><subject>Asphyxia Neonatorum - complications</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Creatinine</subject><subject>Creatinine - blood</subject><subject>Cystatin C</subject><subject>Cystatin C - blood</subject><subject>Female</subject><subject>Fetal Blood - metabolism</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Newborn</subject><subject>ROC Curve</subject><subject>Sensitivity and Specificity</subject><issn>1744-9979</issn><issn>1744-9987</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9PwjAUxxujEUTP3kyPXgb9tY0dF6JARPwdEy9NKW-hODZst8D-e4soV3vpy8vnfdP3KUKXlHSpPz0aCxEkST_uUkZCcYTah87xoY6TFjpzbkkIY4LzU9RiQiQJ6YdtpF_A1is8aFylKlMEA6wcVvhe2U-wuMxwqusK8J2ZF9DgcbGsbYNNgasF4ClsZqUtcJpVnn0EawpVqRyPmnW5NaqXuvWi8cU5OslU7uDi9-6gt9ub18EomDwMx4N0Emjh3x7QKJpRmmVhyEMgvM81EwQ0FX0915QpwpKQ8EwoQYWKVTYDTaKIaB77dswZ76Drfe7all81uEqujNOQ56qAsnaS-qW9Jp_j0d4e1bZ0zkIm19aslG0kJXJnVu7cyZ1H-WPWT1z9htezFcwP_J9KD4R7YGNyaP7Lk6_p419wsJ8zroLtYc5_gIxiv5t8nw7lMHoafUynTD7zb3x9kE0</recordid><startdate>201402</startdate><enddate>201402</enddate><creator>Treiber, Milena</creator><creator>Gorenjak, Maksimiljan</creator><creator>Pecovnik Balon, Breda</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201402</creationdate><title>Serum Cystatin-C as a Marker of Acute Kidney Injury in the Newborn After Perinatal Hypoxia/Asphyxia</title><author>Treiber, Milena ; Gorenjak, Maksimiljan ; Pecovnik Balon, Breda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4054-166b11ff5535e0383c240ec148cdc12a029503f4a414a7afbec0660c375037323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acute kidney injury</topic><topic>Acute Kidney Injury - blood</topic><topic>Acute Kidney Injury - etiology</topic><topic>Asphyxia</topic><topic>Asphyxia Neonatorum - complications</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>Creatinine</topic><topic>Creatinine - blood</topic><topic>Cystatin C</topic><topic>Cystatin C - blood</topic><topic>Female</topic><topic>Fetal Blood - metabolism</topic><topic>Glomerular Filtration Rate</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Newborn</topic><topic>ROC Curve</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Treiber, Milena</creatorcontrib><creatorcontrib>Gorenjak, Maksimiljan</creatorcontrib><creatorcontrib>Pecovnik Balon, Breda</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Therapeutic apheresis and dialysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Treiber, Milena</au><au>Gorenjak, Maksimiljan</au><au>Pecovnik Balon, Breda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Cystatin-C as a Marker of Acute Kidney Injury in the Newborn After Perinatal Hypoxia/Asphyxia</atitle><jtitle>Therapeutic apheresis and dialysis</jtitle><addtitle>Ther Apher Dial</addtitle><date>2014-02</date><risdate>2014</risdate><volume>18</volume><issue>1</issue><spage>57</spage><epage>67</epage><pages>57-67</pages><issn>1744-9979</issn><eissn>1744-9987</eissn><abstract>We evaluated cystatin‐C (cysC) in the umbilical blood as a predictor of acute kidney injury (AKI) after perinatal hypoxia/asphyxia compared with creatinine (Cr). One hundred full‐term newborns were enrolled in the study (50 in a group affected by perinatal hypoxia/asphyxia [AS] and 50 controls). CysC and Cr were measured in blood samples from the umbilical cord at birth (cysC‐umb and Cr‐umb) and from a peripheral vein 3 days later (cysC‐3 and Cr‐3). At birth, the mean level of cysC in healthy term babies was found to be 1.39 ± 0.19 mg/L and 1.34 ± 0.21 mg/L after 3 days of life, not significantly decreased (P = 0.137). The mean of cysC in the AS group was 2.12 ± 0.53 mg/L in cord blood and 1.56 ± 0.32 g/L in day 3 blood samples, also decreased (P < 0.001) and different from the control (P < 0.001). Cr levels, determined simultaneously at birth were different (P = 0.001) between the control (62.74 ± 12.84 μmol/L) and AS (72.60 ± 15.55 μmol/L) group, significantly decreased after 3 days in both groups (P < 0.001). The receiver‐operating characteristic curve analysis, comparing AS and the control group, showed area under the curve for cysC‐umb, cysC‐3, Cr‐umb and Cr‐3 (0.918; 0.698; 0.692; 0.660). The highest diagnostic accuracy was achieved with a chosen cut‐off for cysC‐umb of 1.67 mg/L (sensitivity of 84.0%, specificity of 90.0%) or 1.69 mg/L (sensitivity of 82.0%, specificity of 94.0%). Our results indicate serum CysC is a more sensitive marker of glomerular filtration rate than Cr in the newborns.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>24499085</pmid><doi>10.1111/1744-9987.12054</doi><tpages>11</tpages></addata></record> |
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| subjects | Acute kidney injury Acute Kidney Injury - blood Acute Kidney Injury - etiology Asphyxia Asphyxia Neonatorum - complications Biomarkers - blood Case-Control Studies Creatinine Creatinine - blood Cystatin C Cystatin C - blood Female Fetal Blood - metabolism Glomerular Filtration Rate Humans Hypoxia Infant, Newborn Male Newborn ROC Curve Sensitivity and Specificity |
| title | Serum Cystatin-C as a Marker of Acute Kidney Injury in the Newborn After Perinatal Hypoxia/Asphyxia |
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